Trial reportJournal of the American Geriatrics Society2020
Risks and Benefits of Screening for Dementia in Primary Care: The Indiana University Cognitive Health Outcomes Investigation of the Comparative Effectiveness of Dementia Screening (IU CHOICE)Trial.
Trial report in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Attitudes and Preferences Towards Screening for Dementia From the Perspectives of Healthcare Professionals: An Updated Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- Attitudes and Preferences Towards Screening for Dementia with a Focus on Ethnic Minority and Low Socio-Economic Groups: A Systematic Review of Research Studies Written in the English Language.Journal of Alzheimer's disease : JAD · 2024Pooled it
- Pooled it
- Digital Detection of Dementia in Primary Care: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial.Nature medicine · 2024Trial
- Article
- Impact of national cognitive screening on dementia care and hospitalization in South Korea.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Mental Health and Addiction.Acta medica Philippina · 2026Article
- End User and Primary Care Physicians' Perspectives on Digital Innovations in Dementia Risk Detection: Focus on a Digital Sleep Biomarker.JMIR aging · 2025Article
- What Helps or Hinders Annual Wellness Visits for Detection and Management of Cognitive Impairment Among Older Adults? A Scoping Review Guided by the Consolidated Framework for Implementation Research.Nursing reports (Pavia, Italy) · 2025Review
- Translating lifestyle interventions for optimal brain health in Africa.Nature reviews. Neurology · 2025Review
- Simulated Interviews, Real Results: A feasibility Study Implementing "Standardized Research Participants" cases in Qualitative Research Training with Older Adults.Research square · 2025Article
- Enhancing early detection of cognitive impairment in primary care with the TabCAT-BHA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Feasibility and Acceptability of Implementing a Digital Cognitive Assessment for Alzheimer Disease and Related Dementias in Primary Care.Annals of family medicine · 2025Article
- Feasibility and Acceptability of the "About Me" Care Card as a Tool for Engaging Older Adults in Conversations About Cognitive Impairment.Annals of family medicine · 2025Article
- Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research.The journal of prevention of Alzheimer's disease · 2025Review
- Article
- Adaptation and Validation of the Psychological Consequences of Screening Questionnaire (PCQ) for Cognitive Screening in Primary Care.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- Stakeholder-informed pragmatic trial protocol of the TabCAT-BHA for the detection of cognitive impairment in primary care.BMC primary care · 2024Article
- Relationship between health-related quality of life, depression, and anxiety in older primary care patients and their family members.Aging & mental health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectiveThe benefits and harms of screening of Alzheimer disease and related dementias (ADRDs) are unknown. This study addressed the question of whether the benefits outweigh the harms of screening for ADRDs among older adults in primary care. DESIGN, SETTING, AND
participantsSingle-blinded, two-arm, randomized controlled trial (October 2012-September 2016) in urban, suburban, and rural primary care settings in Indiana. A total of 4005 primary care patients (aged ≥65 years) were randomized to ADRD screening (n = 2008) or control (n = 1997).
interventionPatients were screened using the Memory Impairment Screen or the Mini-Cog and referred for a voluntary follow-up diagnostic assessment if they screened positive on either or both screening tests. MEASUREMENTS: Primary measures were health-related quality of life (HRQOL; Health Utilities Index) at 12 months, depressive symptoms (Patient Health Questionnaire-9), and anxiety symptoms (Generalized Anxiety Disorder seven-item scale) at 1 month.
resultsThe mean age was 74.2 years (SD = 6.9 years); 2257 (66%) were female and 2301 (67%) were white. At 12 months, we were unable to detect differences in HRQOL between the groups (effect size = 0.009 [95% confidence interval {CI} = -0.063 to 0.080]; P = .81). At 1 month, differences in mean depressive symptoms (mean difference = -0.23 [90% CI = -0.42 to -0.039]) and anxiety symptoms (mean difference = -0.087 [90% CI = -0.246 to 0.072]) were within prespecified equivalency range. Scores for depressive and anxiety symptoms were similar between the groups at all time points. No differences in healthcare utilization, advance care planning, and ADRD recognition by physicians were detected at 12 months.
conclusionWe were unable to detect a difference in HRQOL for screening for ADRD among older adults. We found no harm from screening measured by symptoms of depression or anxiety. Missing data, low rates of dementia detection, and high rate of refusal for follow-up diagnostic assessments after a positive screen may explain these findings. J Am Geriatr Soc 68:535-543, 2020.
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