Evidence map›Paper›PMID 31792924›Full record

ArticleThe British journal of dermatology2020

The psychological impact of Stevens-Johnson syndrome and toxic epidermal necrolysis on patients' lives: a Critically Appraised Topic.

P O'Reilly, C Kennedy, P Meskell, A Coffey, I Delaunois, L Dore, S Howard, B Ramsay, C Scanlon, D M Wilson and 2 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

P O'ReillyDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.ORCID 0000-0002-4956-4670
C KennedyDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.
P MeskellDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.
A CoffeyDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.
I DelaunoisRegional Medical Library, University Hospital Limerick, Limerick, Ireland.
L DoreGlucksman Library, University of Limerick, Limerick, Ireland.
S HowardHealth Research Institute, University of Limerick, Limerick, Ireland.
B RamsayCharles Centre for Dermatology, University Hospital Limerick, Limerick, Ireland.
C ScanlonNo affiliation.
D M WilsonDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.
B WhelanDepartment of Nursing and Midwifery, University of Limerick, Limerick, Ireland.
S RyanCharles Centre for Dermatology, University Hospital Limerick, Limerick, Ireland.
University of Limerick · IEUniversity Hospital Limerick · IEUniversity of Alberta · CA

Funding

Health Research Institute, University of Limerick, Ireland
6 · The paper itself

Abstract

clinical scenarioA 65-year-old man presented with a 12-h history of deteriorating rash. Two weeks previously he had completed a course of neoadjuvant chemotherapy for ductal carcinoma of the breast. On examination there were bullae, widespread atypical targetoid lesions and 15% epidermal detachment. There was no mucosal involvement on presentation, but subsequently it did evolve. Skin biopsy showed subepidermal blistering with epidermal necrosis. This confirmed our clinical diagnosis of overlap Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). On transfer to intensive care he was anxious and fearful. MANAGEMENT QUESTION: What are the psychological impacts of SJS/TEN on this man's life?

backgroundSJS and TEN have devastating outcomes for those affected.

objectivesTo conduct a Critically Appraised Topic to (i) analyse existing research related to the psychological impact of SJS and TEN and (ii) apply the results to the clinical scenario.

methodsSeven electronic databases were searched for publications focusing on the psychological impact of SJS/TEN on adults over 18 years of age.

resultsSix studies met the inclusion criteria. Healthcare practitioners' (HCPs') lack of information around the disorder was highlighted. Patients experienced undue stress and fear. Some patients had symptoms aligned to post-traumatic stress disorder (PTSD), anxiety and depression. DISCUSSION AND RECOMMENDATION: The evidence suggests that SJS and TEN impact psychologically on patients' lives. Education of HCPs, to address their lack of awareness and information on SJS/TEN, should facilitate their capacity to provide information and support to patients, thereby reducing patient anxiety. On discharge, a follow-up appointment with relevant HCPs to reduce the possibility of PTSD occurring should be considered.

Indexed as

Stevens-Johnson SyndromeAdolescentAdultAgedCritical CareHumansMaleMucous MembraneRetrospective StudiesSkin

Identifiers

PMID31792924
PMCPMC7687230
OpenAlexW2994439256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.