Evidence map›Paper›PMID 31792853›Full record

ArticleInternational ophthalmology2020

Serum SCUBE-1 levels in patients with diabetic retinopathy.

Erel Icel, Aykut Icel, Cuma Mertoglu, Nurdan Gamze Tasli, Yucel Karakurt, Turgay Ucak, Murat Gunay

Abstract read
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Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Erel IcelOphthalmology Department, School of Medicine, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey. dr_erel@hotmail.com.ORCID http://orcid.org/0000-0001-7150-5581
Aykut IcelInternal Medicine Department, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Cuma MertogluMedical Biochemistry Department, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Nurdan Gamze TasliOphthalmology Department, School of Medicine, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Yucel KarakurtOphthalmology Department, School of Medicine, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Turgay UcakOphthalmology Department, School of Medicine, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Murat GunayMedical Biochemistry Department, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Erzincan Binali Yıldırım University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSignal peptide-CUB-Epidermal growth factor-like domain-containing protein 1 (SCUBE-1) is a protein expressed on the cell surface of endothelial cells and platelets. We aimed to determine the alterations in SCUBE-1 levels in patients at different stages of diabetic retinopathy (DR). MATERIALS AND

methodsParticipants were grouped into 4 regarding the presence and stage of diabetic retinopathy as follows: control group (n 32), patients without DR (n 39), patients with background DR (n 42) and patients with proliferative DR (n 55). Age, gender, duration of diabetes, fasting blood glucose levels, serum hemoglobin A1c (HbA1c), SCUBE-1 and malondialdehyde (MDA) levels of the patients were recorded. Central macular thickness and central macular volume were recorded and compared between groups.

resultsTotally 136 patients with diabetes mellitus and 32 control cases were included in the study. There is a significant increase in SCUBE-1 and MDA levels with an advance in DR. In correlation analysis, there was only a significant correlation present between serum SCUBE-1 and MDA levels (p 0.001) but not with other parameters.

conclusionFor the first time in literature, we determined a significant increase in SCUBE-1 levels in patients with DR. Moreover, with an advance in DR, SCUBE-1 levels were also increasing.

Indexed as

AdultBiomarkersCalcium-Binding ProteinsCase-Control StudiesDiabetic RetinopathyFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsBiomarkersCalcium-Binding ProteinsSCUBE1 protein, humanDiabetic retinopathyMalondialdehydeSCUBE-1

Identifiers

PMID31792853
OpenAlexW2993506327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.