ArticleInternational ophthalmology2020
Reliability of foveal avascular zone metrics automatically measured by Cirrus optical coherence tomography angiography in healthy subjects.
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of caffeine on superficial retinal vasculature of the macula in high myopes using optical coherence tomography angiography - A pilot study.Journal of optometryTrial
- Artificial Intelligence and Eye Disease-Bridging Innovation and Clinical Practice.Journal of clinical medicine · 2026Article
- Inner retinal layers' alterations of the microvasculature in early stages of Parkinson's disease: a cross sectional study.International ophthalmology · 2023Article
- Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review.Journal of ophthalmology · 2023Review
- Disentangled Representation Learning for OCTA Vessel Segmentation With Limited Training Data.IEEE transactions on medical imaging · 2022Article
- Microvascular changes in the macular and parafoveal areas of multiple sclerosis patients without optic neuritis.Scientific reports · 2022Article
- Quantitative assessment and determinants of foveal avascular zone in healthy volunteers.The Journal of international medical research · 2021Article
- Retinal microvasculature dysfunction is associated with Alzheimer's disease and mild cognitive impairment.Alzheimer's research & therapy · 2020Article
- Improved Automated Foveal Avascular Zone Measurement in Cirrus Optical Coherence Tomography Angiography Using the Level Sets Macro.Translational vision science & technology · 2020Article
- Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit.Investigative ophthalmology & visual science · 2020Article
- Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy.Journal of clinical medicine · 2020Review
- Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo investigate the reliability of the foveal avascular zone (FAZ) metrics automatically measured using Cirrus optical coherence tomography angiography (OCTA) embedded algorithm compared to human manual measurement.
methodsThirty-five eyes of 35 healthy subjects were enrolled and scanned four times continuously on Zeiss Cirrus HD-OCT 5000. The FAZ metrics (area, circularity and perimeter) of the superficial capillary plexus were measured automatically using the embedded tool and manually measured by the two independent observers using ImageJ. The repeatability of the four scans within all methods of measurements was calculated. The agreement of the manual vs automated measurement was also analyzed.
resultsThe repeatability of the automated algorithm was only poor to moderate (intraclass correlation coefficients [ICCs] for the area, perimeter and circularity were 0.600, 0.405 and 0.221, respectively) while the repeatability of the manually measured FAZ area and perimeter was good [([ICCs] ranged from 0.845 to 0.877) except the circularity (ICC = 0.538 to 0.608)]. The ranges of 95% limits of agreement between the manual measurements by the two observers were only 20% to 31% of those of automated-manual agreement. The Cirrus inbuilt algorithm obviously outlined the border of FAZ wrongly in 22.9% cases.
conclusionCaution should be taken when using the automated measurement results of FAZ metrics in Cirrus OCTA, because of the low repeatability and poor agreement compared with the manual measurement.
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