ArticleInternational ophthalmology2020
Masqueraders of multiple evanescent white dot syndrome (MEWDS).
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- To treat or not to treat: The clue lies in multimodal imaging.Indian journal of ophthalmology · 2026Article
- From white dot syndromes to primary inflammatory choriocapillaropathies (PICCPs): updating and expanding the spectrum through multimodal imaging.International journal of retina and vitreous · 2026Review
- Bilateral Panuveitis and Placoid Retinitis in Ocular Syphilis Complicated by Subsequent Retinal Detachment.Journal of vitreoretinal diseases · 2026Article
- Beyond placoid: diverse clinical presentations and functional outcomes of acute syphilitic posterior placoid chorioretinopathy.Eye (London, England) · 2026Article
- MEWDS-like Presentation Unmasking Sequential Bilateral Multifocal Choroiditis: Insights from Longitudinal Multimodal Imaging.Biomedicines · 2026Article
- Clinical features in four patients with syphilitic outer retinopathy.Japanese journal of ophthalmology · 2025Article
- Characterization of Syphilitic Chorioretinitis as a White Dot Syndrome with Multimodal Imaging: Case Series.Diagnostics (Basel, Switzerland) · 2025Article
- Multiple evanescent white dot syndrome and presentations similar to multiple evanescent white dot syndrome in other disorders: a narrative review.International journal of ophthalmology · 2025Review
- Photoreceptor Integrity in MEWDS: Longitudinal Structure-Function Correlations.Investigative ophthalmology & visual science · 2024Observational
- Acute-Onset Retinal Conditions Mimicking Acute Optic Neuritis: Overview and Differential Diagnosis.Journal of clinical medicine · 2023Review
- Acute syphilitic posterior placoid chorioretinitis as the presenting symptom of syphilis in an immunocompetent patient.American journal of ophthalmology case reports · 2022Article
- Bacillary layer detachment in serpiginous-like choroiditis of presumed intraocular tuberculosis: Report of two cases.American journal of ophthalmology case reports · 2022Article
- White dot syndrome in a patient with presumed ocular tuberculosis: a case report.International journal of retina and vitreous · 2022Article
- Multiple evanescent white dot syndrome (MEWDS): update on practical appraisal, diagnosis and clinicopathology; a review and an alternative comprehensive perspective.Journal of ophthalmic inflammation and infection · 2021Review
- Vitreoretinal Lymphoma.Cancers · 2021Review
- Classification Criteria For Multiple Evanescent White Dot Syndrome.American journal of ophthalmology · 2021Article
- Syphilitic retinitis presentations: punctate inner retinitis and posterior placoid chorioretinitis.International ophthalmology · 2021Article
- Choroidal nonperfusion on optical coherence tomography angiography in a case of unilateral posterior segment ocular sarcoidosis misdiagnosed as MEWDS.American journal of ophthalmology case reports · 2020Article
- Multiple evanescent white dot syndrome and panuveitis: a case report.Journal of ophthalmic inflammation and infection · 2020Article
- Retinal Diseases that Can Masquerade as Neurological Causes of Vision Loss.Current neurology and neuroscience reports · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe disorders that can masquerade as multiple evanescent white dot syndrome (MEWDS).
designRetrospective, multicenter case series.
participantsPatients who presented with clinical findings compatible with a diagnosis of MEWDS but were ultimately diagnosed with an alternative inflammatory, infectious, or neoplastic disorder.
methodsClinical records and multimodal imaging findings including fundus photography, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and OCT angiography (OCTA) were analyzed.
main outcome measuresInclusion criteria to be defined as a masquerade syndrome for MEWDS included the presence of disseminated grayish-white outer retinal spots that were hyperautofluorescent on FAF and associated with ellipsoid zone (EZ) disruption on OCT.
resultsTwenty-two eyes of 13 patients were identified. All patients presented with the classic findings of MEWDS listed above. A MEWDS-like presentation was bilateral in nine of 13 patients (69%). Final diagnosis was determined on the basis of additional investigations including serologies and biopsy. These diagnoses included syphilis (three patients), lymphoma (three patients), idiopathic multifocal choroiditis (two patients), idiopathic retinal phlebitis (one patient), idiopathic acute zonal occult outer retinopathy (one patient), sarcoidosis (one patient), tuberculosis (one patient), and cancer-associated retinopathy (one patient). The outer retinal lesions and imaging findings resolved with treatment for the associated systemic disorders.
conclusionsWidespread grayish-white outer retinal spots associated with hyperautofluorescence on FAF and disruption of the EZ on OCT are not pathognomonic for MEWDS. A high index of suspicion must be maintained for masqueraders of MEWDS, which can include serious inflammatory, infectious, and neoplastic disorders.
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