Evidence map›Paper›PMID 31792744›Full record

ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2019

The Oligomerization of Glucose Under Plausible Prebiotic Conditions.

Zhao Li, Li Li, Kristin R McKenna, Merranda Schmidt, Pamela Pollet, Leslie Gelbaum, Facundo M Fernández, Ramanarayanan Krishnamurthy, Charles L Liotta

Abstract read
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In one paragraph

Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhao LiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0002-1119-6278
Li LiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0003-2064-2177
Kristin R McKennaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0003-4606-0853
Merranda SchmidtNSF/NASA Center for Chemical Evolution, Alexandria, GA, 30332, USA.
Pamela PolletSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Leslie GelbaumSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Facundo M FernándezSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA. facundo.fernandez@chemistry.gatech.edu.ORCID https://orcid.org/0000-0002-0302-2534
Ramanarayanan KrishnamurthyDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. rkrishna@scripps.edu.ORCID https://orcid.org/0000-0001-5238-610X
Charles L LiottaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA. charles.liotta@chemistry.gatech.edu.ORCID https://orcid.org/0000-0002-7450-6640
Georgia Institute of Technology · USRipon College · USScripps Research Institute · US

Funding

NASA Astrobiology Institute CHE-1504217National Science Foundation CHE-1504217
6 · The paper itself

Abstract

The prebiotic origin of polysaccharides, the largest class of biopolymers by mass in extant biology, has seldom been investigated experimentally. Herein, we report on the acid-catalyzed condensation of aqueous solutions of glucose, a model monosaccharide, under plausible prebiotic conditions employing a wet-dry (night-day) protocol with 0.01 M HCl at 50 °C. This protocol leads to the formation of oligosaccharides containing up to eight monomeric units identified by high resolution mass spectrometry. The regio- and stereochemistry of the oligomeric acetal linkages, as well as the quantitative analysis of glucose conversion, are elucidated by combining

Indexed as

Evolution, ChemicalOrigin of LifeGlucoseMagnetic Resonance SpectroscopyMass SpectrometryGlucoseChemical origin of lifeNMR & MS techniquesOligomerization of glucosePrebiotic chemistryRegio/stereochemistry of acetal linkagesWet-dry cycles

Identifiers

PMID31792744
OpenAlexW2993487095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.