Evidence map›Paper›PMID 31792722›Full record

ArticleParasitology research2020

Atypical Toxoplasma gondii genotype from a sheep and a pig on Fernando de Noronha Island, Brazil, showed different mouse virulence profiles.

Renata Pimentel B Melo, Jonatas C Almeida, Débora C V de Lima, Jéssica C S Carvalho, Wagnner J N Porto, Fernando J R Magalhães, Clare M Hamilton, Frank Katzer, Rinaldo A Mota

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Article in Parasitology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2024
    Article
  4. Article
  5. Outbreak of toxoplasmosis associated with muscular lesions in finishing pigs caused by an atypical Toxoplasma gondii genotype.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Renata Pimentel B MeloDepartment of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil. renatapbm@gmail.com.ORCID http://orcid.org/0000-0001-7162-2745
Jonatas C AlmeidaDepartment of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
Débora C V de LimaDepartment of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
Jéssica C S CarvalhoDepartment of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
Wagnner J N PortoBiological and Health Science Institute, Universidade Federal de Alagoas, Av. Lourival Melo Mota, Tabuleiro do Martins, Maceió, Alagoas, 57072-900, Brazil.
Fernando J R MagalhãesHealth Superintendence, Administração do Distrito Estadual de Fernando de Noronha, Pernambuco, Brazil.
Clare M HamiltonMoredun Research Institute, Pentlands Science Park, Midlothian, Scotland, EH26 0PZ, UK.
Frank KatzerMoredun Research Institute, Pentlands Science Park, Midlothian, Scotland, EH26 0PZ, UK.
Rinaldo A MotaDepartment of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
Universidade Federal Rural de Pernambuco · BRMoredun Research Institute · GBSecretaria de Educação de Pernambuco · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasma gondii is a zoonotic parasite which can infect almost all warm-blooded animals. Toxoplasma gondii isolates from Brazil have greater genetic diversity with a predominance of virulent and atypical genotypes, compared with the Northern Hemisphere. Considering that previous studies have demonstrated a high seroprevalence of T. gondii antibodies in animals from Fernando de Noronha Island, the aim of this study was to isolate, genetically characterize, and determine mouse virulence of isolates of T. gondii from livestock from this Brazilian island. Two T. gondii isolates were obtained by mouse bioassay from brain from one sheep and one pig. Genotyping was performed by PCR-RFLP using 10 genetic markers (SAG1, SAG2, SAG3, BTUB, GRA6, c22- 8, c29-2, PK1, L358, and Apico) and an atypical genotype of T. gondii (ToxoDB #146) was identified for both isolates. Genotyping of four ROP loci indicated different alleles for ROP16 and mouse virulence analysis revealed different profiles (intermediate and low virulence). This is the first report of this genotype being described in a pig and a sheep.

Indexed as

AnimalsBrazilGenetic VariationGenotypeIslandsMiceProtozoan ProteinsSheepSwineToxoplasmaToxoplasmosis, AnimalVirulenceProtozoan ProteinsGenotypingIsolationMouse bioassayVirulence genes

Identifiers

PMID31792722
OpenAlexW2991373121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.