Trial reportAnnals of biomedical engineering2020
Assessing Changes in Airflow and Energy Loss in a Progressive Tracheal Compression Before and After Surgical Correction.
Trial report in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Patient-Specific Computational Fluid Dynamics Modeling of Airway Collapse in Infants With Robin Sequence.International journal for numerical methods in biomedical engineering · 2026Article
- The effect of including dynamic imaging derived airway wall motion in CFD simulations of respiratory airflow in patients with OSA.Scientific reports · 2024Article
- Effects of decongestion on nasal cavity air conditioning efficiency: a CFD cohort study.Scientific reports · 2024Article
- Tracheomalacia Reduces Aerosolized Drug Delivery to the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2024Article
- Influence of catheter thickness on respiratory physiology during less invasive surfactant administration in extremely preterm infants.Frontiers in pediatrics · 2024Article
- Analysis of Upper Airway Flow Dynamics in Robin Sequence Infants Using 4-D Computed Tomography and Computational Fluid Dynamics.Annals of biomedical engineering · 2023Article
- Computational fluid dynamics assessment of congenital tracheal stenosis.Pediatric surgery international · 2022Article
- Fluid dynamic assessment of positive end-expiratory pressure in a tracheostomy tube connector during respiration.Medical & biological engineering & computing · 2022Article
- Airway performance in infants with congenital tracheal stenosis associated with unilateral pulmonary agenesis: effect of tracheal shape on energy flux.Medical & biological engineering & computing · 2022Article
- Evaluation of Airflow Sensitivity to the Truncation Level of a Realistic Human Airway Model in an Accurate Numerical Simulation.Journal of biomedical physics & engineering · 2022Article
- Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.Chest · 2021Article
- Subglottic Stenosis Position Affects Work of Breathing.The Laryngoscope · 2021Article
- Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.Materials (Basel, Switzerland) · 2021Article
- Article
- Increased Work of Breathing due to Tracheomalacia in Neonates.Annals of the American Thoracic Society · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The energy needed to drive airflow through the trachea normally constitutes a minor component of the work of breathing. However, with progressive tracheal compression, patient subjective symptoms can include severe breathing difficulties. Many patients suffer multiple respiratory co-morbidities and so it is important to assess compression effects when evaluating the need for surgery. This work describes the use of computational prediction to determine airflow resistance in compressed tracheal geometries reconstructed from a series of CT scans. Using energy flux analysis, the regions that contribute the most to airway resistance during inhalation are identified. The principal such region is where flow emerging from the zone of maximum constriction undergoes breakup and turbulent mixing. Secondary regions are also found below the tongue base and around the glottis, with overall airway resistance scaling nearly quadratically with flow rate. Since the anatomical extent of the imaged airway varied between scans-as commonly occurs with clinical data and when assessing reported differences between research studies-the effect of sub-glottic inflow truncation is considered. Analysis shows truncation alters the location of jet breakup and weakly influences the pattern of pressure recovery. Tests also show that placing a simple artificial glottis in the inflow to a truncated model can replicate patterns of energy loss in more extensive models, suggesting a means to assess sensitivity to domain truncation in tracheal airflow simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.