ArticleEuropean journal of nuclear medicine and molecular imaging2020
The A/T/N model applied through imaging biomarkers in a memory clinic.
Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial.Alzheimer's research & therapy · 2021Trial
- Investigating AD and non-AD [European journal of nuclear medicine and molecular imaging · 2026Article
- Utility of the Amygdalar Atrophy Scale to Identify Patients With Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Memory Clinic.Neurology · 2026Article
- Unraveling the link between frailty and Alzheimer's disease biomarkers in patients with mild cognitive impairment.GeroScience · 2025Article
- Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Highly specific amyloid and tau PET ligands for ATN classification in suspected Alzheimer's disease patients.Annals of nuclear medicine · 2025Article
- Resilience in Alzheimer's disease: Impact of operationalization and methodological choices.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Establishing tau-PET cut-points for cognitive diagnosis withImaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- A deep learning model for generating [European journal of nuclear medicine and molecular imaging · 2024Article
- Fingerprints of brain disease: connectome identifiability in Alzheimer's disease.Communications biology · 2024Article
- Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The clinical importance of suspected non-Alzheimer disease pathophysiology.Nature reviews. Neurology · 2024Review
- Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients.Alzheimer's research & therapy · 2024Article
- Real-word application of the AT(N) classification and disease-modifying treatment eligibility in a hospital-based cohort.Journal of neurology · 2024Article
- A comparison of visual assessment and semi-quantification for the diagnostic and prognostic use of [European journal of nuclear medicine and molecular imaging · 2024Article
- Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort.Journal of neurology · 2024Article
- The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic.Journal of neurology, neurosurgery, and psychiatry · 2023Article
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18 authors.
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Abstract
purposeThe A/T/N model is a research framework proposed to investigate Alzheimer's disease (AD) pathological bases (i.e., amyloidosis A, neurofibrillary tangles T, and neurodegeneration N). The application of this system on clinical populations is still limited. The aim of the study is to evaluate the topography of T distribution by 18F-flortaucipir PET in relation to A and N and to describe the A/T/N status through imaging biomarkers in memory clinic patients.
methodsEighty-one patients with subjective and objective cognitive impairment were classified as A+/A- and N+/N- through amyloid PET and structural MRI. Tau deposition was compared across A/N subgroups at voxel level. T status was defined through a global cut point based on A/N subgroups and subjects were categorized following the A/T/N model.
resultsA+N+ and A+N- subgroups showed higher tau burden compared to A-N- group, with A+N- showing significant deposition limited to the medial and lateral temporal regions. Global cut point discriminated A+N+ and A+N- from A-N- subjects. On A/T/N classification, 23% of patients showed a negative biomarker profile, 58% fell within the Alzheimer's continuum, and 19% of the sample was characterized by non-AD pathologic change.
conclusionMedial and lateral temporal regions represent a site of significant tau accumulation in A+ subjects and possibly a useful marker of early clinical changes. This is the first study in which the A/T/N model is applied using 18F-flortaucipir PET in a memory clinic population. The majority of patients showed a profile consistent with the Alzheimer's continuum, while a minor percentage showed a profile suggestive of possible other neurodegenerative diseases. These results support the applicability of the A/T/N model in clinical practice.
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