Evidence map›Paper›PMID 31792569›Full record

ArticleNeuroradiology2020

Abnormal brain white matter in patients with hemifacial spasm: a diffusion tensor imaging study.

Chenguang Guo, Hui Xu, Xuan Niu, Samuel Krimmel, Jixin Liu, Lin Gao, Ming Zhang, Yuan Wang

Abstract read
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In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chenguang GuoDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Hui XuDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Xuan NiuDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Samuel KrimmelDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
Jixin LiuCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, 710126, People's Republic of China.
Lin GaoKey Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Ming ZhangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Yuan WangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. wangyuan8003@126.com.ORCID http://orcid.org/0000-0002-5692-2659
First Affiliated Hospital of Xi'an Jiaotong University · CNUniversity of Maryland, Baltimore · USXi'an Jiaotong University · CNXidian University · CN

Funding

Fundamental Research Funds for the Central Universities in Xi'an Jiaotong University xjj2018272Natural Science Foundation of Shaanxi Province 2018JM7026Xi'an Science and Technology Project 201805102YX10SF36(3)
6 · The paper itself

Abstract

purposeRefractory hemifacial contraction and comorbid emotional disorders are major annoyance suffered by patients with hemifacial spasm (HFS). It is currently unknown how whiter matter (WM) abnormalities in the brain contribute to HFS.

methodsTo investigate WM alterations in HFS, 26 patients and 29 matched healthy controls were ultimately recruited in this experiment. The whole brain diffusion tensor imaging (DTI) was acquired at 3.0 Tesla scanner. Tract-based spatial statistics (TBSS) analysis was applied to investigate the differences of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) axial diffusivity (AD)) between HFS patients and controls throughout brain WM. The relationship between the severity of facial spasm and affective disturbance in HFS patients, and WM abnormalities was examined using spearman correlation analyses.

resultsTBSS method showed structural alterations in the genu and body of corpus callosum; bilateral inferior longitudinal fasciculus (ILF) and inferior frontal-occipital fasciculus (IFOF); left superior longitudinal fasciculus, anterior, posterior, and superior portion of corona radiata; left posterior limb of the internal capsule; and left posterior thalamic radiation in HFS patients compared with healthy subjects. In addition, the overlapped region of decreased FA together with increased RD and MD was merely localized in the right ILF and IFOF in the HFS group, and abnormality of RD value in this region was positively correlated with the patients' spasm score.

conclusionsThe present study indicate extensive disruptions of WM integrity, especially the RD changes in right ILF and IFOF, which may provide alternative imaging clues for evaluating the characteristics of HFS.

Indexed as

Hemifacial SpasmAnisotropyCase-Control StudiesDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedNeuropsychological TestsWhite MatterDiffusion tensor imagingHemifacial spasmTract-based spatial statisticsWhite matter

Identifiers

PMID31792569
OpenAlexW2992369828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.