Evidence map›Paper›PMID 31792431›Full record

ReviewNature reviews. Urology2020

Financial toxicity associated with treatment of localized prostate cancer.

Brandon S Imber, Melissa Varghese, Behfar Ehdaie, Daniel Gorovets

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Phase 1 Trial of Image Guided Risk Volume-Adapted Postprostatectomy Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling.Medical oncology (Northwood, London, England) · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. A prospective evaluation of patient perspectives and financial considerations during prostate cancer treatment decision-making.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brandon S ImberDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1281-5915
Melissa VargheseDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Behfar EhdaieDepartment of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniel GorovetsDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. gorovetd@mskcc.org.ORCID http://orcid.org/0000-0003-0529-0812
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Financial toxicity is a broad term to describe the economic consequences and subjective burden resulting from a cancer diagnosis and treatment. As financial toxicity is associated with poor disease outcomes, recognition of this problem and calls for strategies to identify and support those most at risk are increasing. Men with localized prostate cancer face treatment choices including active surveillance, prostatectomy or radiotherapy. The fact that potential patient out-of-pocket costs might influence decision making has rarely been acknowledged and, overall, the risk of financial toxicity for men with localized prostate cancer remains poorly studied. This shortfall requires a work-up in the context of prostate cancer and a multidimensional framework for considering a patient's risk of financial toxicity. The major elements of this framework are direct and indirect costs, patient-specific values, expectations of possible financial burdens, and individual economic circumstances. Current data indicate that total cost patterns probably differ by treatment modality: surgery might have an increased short-term effect, whereas radiotherapy might have an increased long-term risk of financial toxicity. Specific thresholds of patient income levels or out-of-pocket costs that predict risk of financial toxicity are difficult to identify. Compared with other malignancies, prostate cancer might have a lower overall risk of financial toxicity, but persistent post-treatment urinary, bowel or sexual adverse effects are likely to increase this risk.

Indexed as

Cost of IllnessHealth Care CostsHumansMaleProstatic Neoplasms

Identifiers

PMID31792431
PMCPMC8010900
OpenAlexW2990176706

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.