ArticleNature biomedical engineering2020
Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 72 citations in OpenAlex.
- Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration.Ophthalmology · 2020Trial
- Photovoltaic nanoassembly of nanowire arrays sensitized with colloidal nanocrystals for near-infrared retina photostimulation.Science advances · 2026Article
- A flexible photoacoustic retinal prosthesis.Nature communications · 2025Article
- A flexible photoacoustic retinal prosthesis.bioRxiv : the preprint server for biology · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Ultrathin rubbery bio-optoelectronic stimulators for untethered cardiac stimulation.Science advances · 2024Article
- Rodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals.Cold Spring Harbor perspectives in medicine · 2024Review
- Evolution of Retinal Neuron Fractality When Interfacing with Carbon Nanotube Electrodes.Bioengineering (Basel, Switzerland) · 2024Article
- Retinitis Pigmentosa and Therapeutic Approaches: A Systematic Review.Journal of clinical medicine · 2024Review
- Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors.Nature biomedical engineering · 2024Article
- Capacitive and Efficient Near-Infrared Stimulation of Neurons via an Ultrathin AgBiSACS applied materials & interfaces · 2024Article
- Article
- Fractal Electronics for Stimulating and Sensing Neural Networks: Enhanced Electrical, Optical, and Cell Interaction Properties.Advances in neurobiology · 2024Article
- Prosthetic Visual Acuity with the PRIMA System in Patients with Atrophic Age-related Macular Degeneration at 4 years follow-up.medRxiv : the preprint server for health sciences · 2023Article
- Metaverse Wearables for Immersive Digital Healthcare: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management.Chemical reviews · 2023Review
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Inducible nonhuman primate models of retinal degeneration for testing end-stage therapies.Science advances · 2023Article
- Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices.RSC advances · 2023Article
- Comparison of fractal and grid electrodes for studying the effects of spatial confinement on dissociated retinal neuronal and glial behavior.Scientific reports · 2022Article
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Authors and funding
33 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.