Evidence map›Paper›PMID 31792411›Full record

ArticleNature biotechnology2019

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia.

Jeffrey M Granja, Sandy Klemm, Lisa M McGinnis, Arwa S Kathiria, Anja Mezger, M Ryan Corces, Benjamin Parks, Eric Gars, Michaela Liedtke, Grace X Y Zheng and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 324 papers.

0numbers the graph read from it
0cells of the map it votes in
324citing papers in PubMed
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

324 citing papers in PubMed, 549 citations in OpenAlex.

  1. Azacitidine, Venetoclax, and Magrolimab in Newly Diagnosed and Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/II Study and Correlative Analysis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
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  8. Organism-scale annotation with Pan-human Azimuth.bioRxiv : the preprint server for biology · 2026
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  11. Review
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  15. EpiATLAS - a reference for human epigenomic research.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
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  19. International journal of molecular sciences · 2026
    Article
  20. Article

264 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jeffrey M Granja *Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Sandy Klemm *Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. klemm@stanford.edu.ORCID http://orcid.org/0000-0001-7556-6795
Lisa M McGinnis *Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. lisa.mcginnis@stanford.edu.
Arwa S KathiriaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Anja MezgerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
M Ryan CorcesCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Benjamin ParksDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0261-7472
Eric GarsDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Michaela LiedtkeDepartment of Medicine, Division of Hematology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Grace X Y Zheng10x Genomics, Pleasanton, CA, USA.ORCID http://orcid.org/0000-0002-5006-3785
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9459-4393
Ravindra MajetiDepartment of Medicine, Division of Hematology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
William J GreenleafCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA. wjg@stanford.edu.ORCID http://orcid.org/0000-0003-1409-3095
Stanford University · USChan Zuckerberg Initiative (United States) · USHoward Hughes Medical Institute · USKarolinska Institutet · SEStanford Medicine · US

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOMEUM1HG009442 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2017 to 2021
$20.1M
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI GREENLEAF, WILLIAM JAMES · 2014 to 2018
$15.2M
Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8M
LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
High-throughput systematic characterization of regulatory element functionUM1HG009436 · NHGRI · STANFORD UNIVERSITY · PI BASSIK, MICHAEL C, GREENLEAF, WILLIAM JAMES · 2017 to 2021
$5.4M
Functional characterization of the Alzheimer's disease epigenomeK99AG059918 · NIA · STANFORD UNIVERSITY · PI CORCES, MICHAEL RYAN · 2018 to 2019
$251k
NCI NIH HHS R35 CA209919NHGRI NIH HHS P50 HG007735NHGRI NIH HHS RM1 HG007735NHGRI NIH HHS UM1 HG009436NHGRI NIH HHS UM1 HG009442NIAID NIH HHS U19 AI057266NIA NIH HHS K99 AG059918
6 · The paper itself

Abstract

Identifying the causes of human diseases requires deconvolution of abnormal molecular phenotypes spanning DNA accessibility, gene expression and protein abundance

Indexed as

Bone Marrow CellsChromatinCluster AnalysisCore Binding Factor Alpha 2 SubunitEpigenesis, GeneticEpigenomicsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLeukemia, Biphenotypic, AcuteRegulatory Sequences, Nucleic AcidSingle-Cell AnalysisTranscriptomeChromatinCore Binding Factor Alpha 2 SubunitRUNX1 protein, human

Identifiers

PMID31792411
PMCPMC7258684
OpenAlexW2991023348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.