ReviewNature cell biology2019
Human germline genome editing.
Review in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos.Molecular therapy. Nucleic acids · 2023Article
- Mapping the 'Ethical' Controversy of Human Heritable Genome Editing: a Multidisciplinary Approach.Asian bioethics review · 2023Article
- Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic.Medicine, health care, and philosophy · 2023Article
- Cannabis- and Substance-Related Epidemiological Patterns of Chromosomal Congenital Anomalies in Europe: Geospatiotemporal and Causal Inferential Study.International journal of environmental research and public health · 2022Article
- Responsible governance of human germline genome editing in China†.Biology of reproduction · 2022Article
- Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Genome editing approaches using reproductive cells/tissues in flowering plants.Frontiers in genome editing · 2022Review
- Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing.Nature communications · 2021Article
- Detection of a biolistic delivery of fluorescent markers and CRISPR/Cas9 to the pollen tube.Plant reproduction · 2021Article
- Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality.Reproductive medicine and biology · 2021Review
- Gene therapy: a double-edged sword with great powers.Molecular and cellular biochemistry · 2020Review
- Ready for Repair? Gene Editing Enters the Clinic for the Treatment of Human Disease.Molecular therapy. Methods & clinical development · 2020Review
- Harnessing the potential of CRISPR-based platforms to advance the field of hospital medicine.Expert review of anti-infective therapy · 2020Review
- Gene editing and CRISPR in the clinic: current and future perspectives.Bioscience reports · 2020Review
- Germline Genome Editing Research: What Are Gamete Donors (Not) Informed About in Consent Forms?The CRISPR journal · 2020Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
With the advent of efficient, easy-to-use genome editing by CRISPR-Cas9, editing human embryos is now possible, providing tremendous opportunities to study gene function and cell fate in early human development. The technique can also be used to modify the human germline. Unresolved questions about pre-implantation human development could be addressed by basic research using CRISPR-Cas9. In this Perspective, we discuss advances in human genome editing and consider ethical questions and potential clinical implications of this technology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.