Evidence map›Paper›PMID 31792370›Full record

Trial reportThe pharmacogenomics journal2020

HLA-A*02:01 allele is associated with tanshinone-induced cutaneous drug reactions in Chinese population.

Qinyuan Zhu, Yanzhou Zhang, Jiekun Xuan, Fanping Yang, Binbin Du, Sheng-An Chen, Sijia Yan, Menglin Jiang, Huizhong Zhu, Hao Xiong and 2 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in The pharmacogenomics journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Progress in study on the association between HLA genetic variation and adverse drug reactions.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qinyuan ZhuDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Jing'an District, Shanghai, China.
Yanzhou ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jiekun XuanSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, China.
Fanping YangDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Jing'an District, Shanghai, China.
Binbin DuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Sheng-An ChenDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Jing'an District, Shanghai, China.
Sijia YanChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
Menglin JiangChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
Huizhong ZhuChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
Hao XiongDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Jing'an District, Shanghai, China.
Xiaoqun LuoDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Jing'an District, Shanghai, China. luoxiaoqun913@126.com.
Qinghe XingChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China. xingqinghe@hotmail.com.
Children's Hospital of Fudan University · CNFudan University · CNFirst Affiliated Hospital of Zhengzhou University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tanshinone, a widely used Chinese patent medicine, has been confirmed to have various kinds of pharmacological effects although frequently causing cutaneous adverse drug reactions (cADRs). We aim to identify whether human leukocyte antigen (HLA) class I alleles are associated with tanshinone-induced cADRs in Han Chinese. The association study including 18 patients with tanshinone-induced cADRs, 67 tanshinone-tolerant volunteers, and two general population databases consisted of 10,689 and 169,995 healthy subjects was performed. The frequency of tanshinone-induced cADRs patients carrying HLA-A*02:01 was significantly higher when compared with the general control groups (OR = 6.25, Pc = 7.20 × 10

Indexed as

AllelesAbietanesAdolescentAdultAgedAnti-Infective AgentsAsian PeopleDrug EruptionsFemaleGenetic Association StudiesHLA-A2 AntigenHumansMaleMiddle AgedMolecular Docking SimulationPopulation SurveillanceAbietanesAnti-Infective AgentsHLA-A*02:01 antigenHLA-A2 Antigentanshinone

Identifiers

PMID31792370
OpenAlexW2990202568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.