ArticleScientific reports2019
Metabolic shift induced by synthetic co-cultivation promotes high yield of chain elongated acids from syngas.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Synthetic Microbial Cocultivation for Targeted Production of Odd-Chain Carboxylates and Alcohols from Carbon Monoxide.Environmental science & technology · 2025Article
- Article
- Immobilization and Monitoring ofMicroorganisms · 2025Article
- Implementation of aComputational and structural biotechnology journal · 2025Article
- Influence of Hydrogen and Ethanol Addition in Methanogen-Free Mixed Culture Syngas Fermentations in Trickle Bed Reactors.Molecules (Basel, Switzerland) · 2024Article
- Article
- Lactate-mediated mixotrophic co-cultivation of Clostridium drakei and recombinant Acetobacterium woodii for autotrophic production of volatile fatty acids.Microbial cell factories · 2024Article
- The role of ethanol oxidation during carboxydotrophic growth of Clostridium autoethanogenum.Microbial biotechnology · 2023Article
- Acetic acid, growth rate, and mass transfer govern shifts in CO metabolism of Clostridium autoethanogenum.Applied microbiology and biotechnology · 2023Article
- A structured evaluation of genome-scale constraint-based modeling tools for microbial consortia.PLoS computational biology · 2023Article
- Upgrading dilute ethanol to odd-chain carboxylic acids by a synthetic co-culture of Anaerotignum neopropionicum and Clostridium kluyveri.Biotechnology for biofuels and bioproducts · 2023Article
- Overflow metabolism at the thermodynamic limit of life: How carboxydotrophic acetogens mitigate carbon monoxide toxicity.Microbial biotechnology · 2023Article
- Production of biofuels from CMicrobial biotechnology · 2023Review
- Formate-induced CO tolerance and methanogenesis inhibition in fermentation of syngas and plant biomass for carboxylate production.Biotechnology for biofuels and bioproducts · 2023Article
- Artificial microbial consortia for bioproduction processes.Engineering in life sciences · 2023Review
- Synthetic co-culture of autotrophic Clostridium carboxidivorans and chain elongating Clostridium kluyveri monitored by flow cytometry.Microbial biotechnology · 2022Article
- Process Engineering Aspects for the Microbial Conversion of C1 Gases.Advances in biochemical engineering/biotechnology · 2022Article
- The potential of caproate (hexanoate) production usingFrontiers in bioengineering and biotechnology · 2022Article
- Faster Growth Enhances Low Carbon Fuel and Chemical Production Through Gas Fermentation.Frontiers in bioengineering and biotechnology · 2022Article
- Model-driven approach for the production of butyrate from COFrontiers in microbiology · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bio-catalytic processes for sustainable production of chemicals and fuels receive increased attention within the concept of circular economy. Strategies to improve these production processes include genetic engineering of bio-catalysts or process technological optimization. Alternatively, synthetic microbial co-cultures can be used to enhance production of chemicals of interest. It remains often unclear however how microbe to microbe interactions affect the overall production process and how this can be further exploited for application. In the present study we explored the microbial interaction in a synthetic co-culture of Clostridium autoethanogenum and Clostridium kluyveri, producing chain elongated products from carbon monoxide. Monocultures of C. autoethanogenum converted CO to acetate and traces of ethanol, while during co-cultivation with C. kluyveri, it shifted its metabolism significantly towards solventogenesis. In C. autoethanogenum, expression of the genes involved in the central carbon- and energy-metabolism remained unchanged during co-cultivation compared to monoculture condition. Therefore the shift in the metabolic flux of C. autoethanogenum appears to be regulated by thermodynamics, and results from the continuous removal of ethanol by C. kluyveri. This trait could be further exploited, driving the metabolism of C. autoethanogenum to solely ethanol formation during co-cultivation, resulting in a high yield of chain elongated products from CO-derived electrons. This research highlights the important role of thermodynamic interactions in (synthetic) mixed microbial communities and shows that this can be exploited to promote desired conversions.
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