Evidence map›Paper›PMID 31792184›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Endogenous retroviruses are associated with hippocampus-based memory impairment.

Roman Sankowski, Joshua J Strohl, Tomás S Huerta, Elham Nasiri, Andrea N Mazzarello, Cristina D'Abramo, Kai Fan Cheng, Ori Staszewski, Marco Prinz, Patricio T Huerta and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
7.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Roman SankowskiCenter for Molecular Innovation, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Joshua J StrohlLaboratory of Immune & Neural Networks, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Tomás S HuertaLaboratory of Immune & Neural Networks, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Elham NasiriCenter for Molecular Innovation, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Andrea N MazzarelloKarches Center for Oncology Research, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Cristina D'AbramoLitwin-Zucker Center for Alzheimer's Disease & Memory Disorders, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Kai Fan ChengCenter for Molecular Innovation, Feinstein Institutes for Medical Research, Manhasset, NY 11030.
Ori StaszewskiInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany.
Marco PrinzInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany.
Patricio T HuertaLaboratory of Immune & Neural Networks, Feinstein Institutes for Medical Research, Manhasset, NY 11030; phuerta@northwell.edu yalabed@northwell.edu.
Yousef Al-AbedCenter for Molecular Innovation, Feinstein Institutes for Medical Research, Manhasset, NY 11030; phuerta@northwell.edu yalabed@northwell.edu.
Feinstein Institute for Medical Research · USUniversity of Freiburg · DEHofstra University · US

Funding

The Monoclonal Antibody and Reagent CoreP01AI073693 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Cynthia Aranow · 2008 to 2026
$45.8M
Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI VOLPE, BRUCE THOMAS · 2014 to 2018
$11.5M
NIAID NIH HHS P01 AI073693NIAID NIH HHS P01 AI102852
6 · The paper itself

Abstract

Retrotransposons compose a staggering 40% of the mammalian genome. Among them, endogenous retroviruses (ERV) represent sequences that closely resemble the proviruses created from exogenous retroviral infection. ERVs make up 8 to 10% of human and mouse genomes and range from evolutionarily ancient sequences to recent acquisitions. Studies in

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBehavior, AnimalBrainCognitive DysfunctionDisease Models, AnimalDNA Transposable ElementsEndogenous RetrovirusesGene Expression RegulationGene Products, gagHippocampusLearningMaleMembrane ProteinsMemoryMemory DisordersAdaptor Proteins, Signal TransducingDNA Transposable ElementsGene Products, gagMAVS protein, mouseMembrane ProteinsSting1 protein, mouseSTING ProteinStreptozocincognitive impairmentendogenous retrovirushippocampusinflammationlearning and memory

Identifiers

PMID31792184
PMCPMC6925997
OpenAlexW2992551893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.