ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Stimulation Augments Spike Sequence Replay and Memory Consolidation during Slow-Wave Sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Hippocampal indexing alters the stability landscape of synaptic weight space allowing life-long learning.bioRxiv : the preprint server for biology · 2025Article
- Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration.Journal of sleep research · 2025Article
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Possible mechanisms to improve sleep spindles via closed loop stimulation during slow wave sleep: A computational study.PloS one · 2024Article
- The role of age-related sleep EEG changes in memory decline: experiments and computational modeling.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Sleep prevents catastrophic forgetting in spiking neural networks by forming a joint synaptic weight representation.PLoS computational biology · 2022Article
- Decoding cognition from spontaneous neural activity.Nature reviews. Neuroscience · 2022Review
- Modulating role of serotonergic signaling in sleep and memory.Pharmacological reports : PR · 2022Review
- Differential thalamocortical interactions in slow and fast spindle generation: A computational model.PloS one · 2022Article
- Therapy for Alzheimer's disease: Missing targets and functional markers?Ageing research reviews · 2021Review
- Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.PLoS computational biology · 2021Article
- Replay of innate vocal patterns during night sleep in suboscines.Proceedings. Biological sciences · 2021Article
- Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep.PLoS computational biology · 2021Article
- Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Newly acquired memory traces are spontaneously reactivated during slow-wave sleep (SWS), leading to the consolidation of recent memories. Empirical studies found that sensory stimulation during SWS can selectively enhance memory consolidation with the effect depending on the phase of stimulation. In this new study, we aimed to understand the mechanisms behind the role of sensory stimulation on memory consolidation using computational models implementing effects of neuromodulators to simulate transitions between awake and SWS sleep, and synaptic plasticity to allow the change of synaptic connections due to the training in awake or replay during sleep. We found that when closed-loop stimulation was applied during the Down states of sleep slow oscillation, particularly right before the transition from Down to Up state, it significantly affected the spatiotemporal pattern of the slow waves and maximized memory replay. In contrast, when the stimulation was presented during the Up states, it did not have a significant impact on the slow waves or memory performance after sleep. For multiple memories trained in awake, presenting stimulation cues associated with specific memory trace could selectively augment replay and enhance consolidation of that memory and interfere with consolidation of the others (particularly weak) memories. Our study proposes a synaptic-level mechanism of how memory consolidation is affected by sensory stimulation during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.