Evidence map›Paper›PMID 31792059›Full record

ArticleLife science alliance2019

Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Female-specificMolecular neurodegeneration advances · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Stefka GyonevaAcute Neurology, Biogen, Cambridge, MA, USA Stefka.gyoneva@biogen.com.ORCID 0000-0001-7714-9450
Raghavendra HosurComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
David GosselinCell and Molecular Medicine, University of California San Diego, San Diego, CA, USA.
Baohong ZhangComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
Zhengyu OuyangCell and Molecular Medicine, University of California San Diego, San Diego, CA, USA.
Anne C CotleurAcute Neurology, Biogen, Cambridge, MA, USA.ORCID 0000-0003-4571-6435
Michael PetersonTranslational Neuropathology, Biogen, Cambridge, MA, USA.ORCID 0000-0003-0337-6049
Norm AllaireComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
Ravi ChallaComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
Patrick CullenComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
Chris RobertsComputational Biology and Genomics, Biogen, Cambridge, MA, USA.
Kelly MiaoAcute Neurology, Biogen, Cambridge, MA, USA.
Taylor L ReynoldsTranslational Neuropathology, Biogen, Cambridge, MA, USA.
Christopher K GlassCell and Molecular Medicine, University of California San Diego, San Diego, CA, USA.ORCID 0000-0003-4344-3592
Linda BurklyAcute Neurology, Biogen, Cambridge, MA, USA.
Richard M RansohoffAcute Neurology, Biogen, Cambridge, MA, USA Richard_Ransohoff@hms.harvard.edu.ORCID 0000-0003-0175-6910
Biogen (United States) · USUniversity of California San Diego · US

Funding

Mechanisms controlling human microglia gene expressionR01NS096170 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2016 to 2025
$4.3M
NINDS NIH HHS R01 NS096170
6 · The paper itself

Abstract

CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying

Indexed as

Aging, PrematureAnimalsCX3C Chemokine Receptor 1Disease Models, AnimalFemaleGene DeletionGenetic ProfileInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrogliaNeuronsCX3C Chemokine Receptor 1Cx3cr1 protein, mouseLipopolysaccharidesReceptors, Chemokine

Identifiers

PMID31792059
PMCPMC6892408
OpenAlexW2994105471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.