Evidence map›Paper›PMID 31791719›Full record

ArticleTrends in immunology2020

Detrimental Role of Neutrophil Extracellular Traps during Dengue Virus Infection.

Claudia Schulz, Gülsah Gabriel, Maren von Köckritz-Blickwede

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  11. Receptor-Mediated NETosis on Neutrophils.Frontiers in immunology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Claudia SchulzResearch Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany.
Gülsah GabrielViral Zoonosis-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; Institute of Virology, University of Veterinary Medicine, Hannover, Germany.
Maren von Köckritz-BlickwedeResearch Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: mkoeckbl@tiho-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent article by Sung et al. identified the CLEC2 platelet receptor as an important factor of lethal dengue virus infection. Formation of neutrophil extracellular traps via crosstalk with CLEC5A and TLR2 neutrophils were ascribed a causative role in DENV infection. This provides new insights for the development of candidate broad-spectrum therapies against hemorrhagic virus infections.

Indexed as

Dengue VirusExtracellular TrapsExtracellular VesiclesInfectionsBlood PlateletsHumansLectins, C-TypeReceptors, Cell SurfaceToll-Like Receptor 2CLEC5A protein, humanLectins, C-TypeReceptors, Cell SurfaceTLR2 protein, humanToll-Like Receptor 2dengue virusinfluenza virusneutrophil extracellular trapsneutrophilsplatelets

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.