Evidence map›Paper›PMID 31791442›Full record

ArticleJournal of the International Neuropsychological Society : JINS2020

Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study.

Astrid Suchy-Dicey, Dean Shibata, Brenna Cholerton, Lonnie Nelson, Darren Calhoun, Tauqeer Ali, Thomas J Montine, W T Longstreth, Dedra Buchwald, Steven P Verney

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Astrid Suchy-DiceyInitiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.
Dean ShibataDepartment of Radiology, University of Washington, Seattle, WA, USA.
Brenna CholertonDepartment of Pathology, Stanford University, Palo Alto, CA, USA.
Lonnie NelsonCollege of Nursing, Washington State University, Seattle, WA, USA.
Darren CalhounPhoenix Field Office MedStar Research Institute, Phoenix, AZ, USA.
Tauqeer AliCenter for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Thomas J MontineDepartment of Pathology, Stanford University, Palo Alto, CA, USA.
W T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
Dedra BuchwaldInitiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.
Steven P VerneyDepartment of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0003-2648-8182
Palo Alto University · USUniversity of Washington · USWashington State University · USPhoenix (United States) · USUniversity of New Mexico · USUniversity of Oklahoma Health Sciences Center · USWashington State University Vancouver · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
Transdisciplinary Research, Equity and Engagement Center for Advancing Behavioral HealthU54MD004811 · NIMHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CACARI STONE, LISA MARIE, CRUZ, THERESA · 2017 to 2022
$8.7M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
Cerebrovascular Disease and its Consequences in the Strong Study CohortR01HL093086 · NHLBI · WASHINGTON STATE UNIVERSITY · PI BUCHWALD, DEDRA S · 2009 to 2013
$7.3M
CVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
CVD in American Indians Biomarker lab and Arizona Field CenterR01HL109319 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2013 to 2017
$3.6M
CVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2M
Rhythm and Timing Exercises for Cerebral Vascular Disease in American Indians - Diversity Supplement ResubmissionR01AG049084 · NIA · UNIVERSITY OF NEW MEXICO · PI VERNEY, STEVEN P. · 2015 to 2019
$2.3M
NHLBI NIH HHS R01 HL093086NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS K01 AG057821NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG049084NIMHD NIH HHS U54 MD004811
6 · The paper itself

Abstract

objectiveAmerican Indians experience substantial health disparities relative to the US population, including vascular brain aging. Poorer cognitive test performance has been associated with cranial magnetic resonance imaging findings in aging community populations, but no study has investigated these associations in elderly American Indians.

methodsWe examined 786 American Indians aged 64 years and older from the Cerebrovascular Disease and its Consequences in American Indians study (2010-2013). Cranial magnetic resonance images were scored for cortical and subcortical infarcts, hemorrhages, severity of white matter disease, sulcal widening, ventricle enlargement, and volumetric estimates for white matter hyperintensities (WMHs), hippocampus, and brain. Participants completed demographic, medical history, and neuropsychological assessments including testing for general cognitive functioning, verbal learning and memory, processing speed, phonemic fluency, and executive function.

resultsProcessing speed was independently associated with the presence of any infarcts, white matter disease, and hippocampal and brain volumes, independent of socioeconomic, language, education, and clinical factors. Other significant associations included general cognitive functioning with hippocampal volume. Nonsignificant, marginal associations included general cognition with WMH and brain volume; verbal memory with hippocampal volume; verbal fluency and executive function with brain volume; and processing speed with ventricle enlargement.

conclusionsBrain-cognition associations found in this study of elderly American Indians are similar to those found in other racial/ethnic populations, with processing speed comprising an especially strong correlate of cerebrovascular disease. These findings may assist future efforts to define opportunities for disease prevention, to conduct research on diagnostic and normative standards, and to guide clinical evaluation of this underserved and overburdened population.

Indexed as

Cerebrovascular DisordersCognitive AgingCognitive DysfunctionHealth Status DisparitiesAgedAged, 80 and overAmerican Indian or Alaska NativeCohort StudiesFemaleHealth SurveysHumansMagnetic Resonance ImagingMaleMiddle AgedCerebrovascular disordersCognitive agingCultural diversityHealth status disparitiesIndiansMagnetic resonance imagingNeuropsychological testsNorth AmericanVascular brain injury

Identifiers

PMID31791442
PMCPMC7083690
OpenAlexW2992051066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.