ReviewCritical care (London, England)2019
Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice.
Review in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Incidence rate and risk factors of ventilator-associated pneumonia in neurocritical patients with acute cerebrovascular diseases: A systematic review and meta-analysis of observational studies.The Journal of international medical research · 2026Pooled it
- Tracheostomy timing and outcome in critically ill patients with stroke: a meta-analysis and meta-regression.Critical care (London, England) · 2023Pooled it
- Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Effect of modified air-pulse stimulation on tracheotomised patients with dysphagia after stroke: A randomized clinical trial.Medicine · 2026Trial
- Effect of driving pressure on early postoperative lung gas distribution in supratentorial craniotomy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- Sedation in Acute Ischemic Stroke: Pathophysiological Basis and Evidence for Commonly Used Agents.Translational stroke research · 2026Review
- Efficacy of Ceftazidime/Avibactam versus colistin methanesulfonate in treating pulmonary infections caused by Gram-negative bacillis after craniocerebral surgery and analysis of risk factors influencing clinical outcomes: a retrospective study.BMC infectious diseases · 2026Article
- Intubation duration after general anesthesia for thrombectomy in acute ischemic stroke: a cohort study.Frontiers in neurology · 2026Article
- Multidisciplinary and stratified non-pharmacological airway clearance intervention to prevent stroke-associated pneumonia: a quasi-experimental study.European clinical respiratory journal · 2026Article
- Risk factors for prolonged mechanical ventilation in critically ill patients with ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- C-reactive protein to albumin ratio and Glasgow Coma Scale score as the predictors for weaning outcomes in traumatic brain injury.Annals of medicine · 2025Article
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Review
- Predicting Delayed Extubation After General Anesthesia in Postanesthesia Care Unit Patients Using Machine Learning: Model Development Study.JMIR medical informatics · 2025Article
- Pathophysiology and clinical applications of PEEP in acute brain injury.Intensive care medicine · 2025Review
- Optimal timing for tracheostomy in severe ischemic stroke patients: early or standard incision?BMC neurology · 2025Article
- Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives.Respiratory research · 2025Review
- Airway management and functional outcomes in intubated patients with ischemic stroke.Scientific reports · 2025Article
- Development of Extubation Success Prediction Model for Mechanically Ventilated Patients with Spontaneous Cerebellar Hemorrhage.Cerebellum (London, England) · 2024Article
- Anesthetic Management of Acute Ischemic Stroke Undergoing Mechanical Thrombectomy: An Overview.Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most patients with ischaemic stroke are managed on the ward or in specialty stroke units, but a significant number requires higher-acuity care and, consequently, admission to the intensive care unit. Mechanical ventilation is frequently performed in these patients due to swallowing dysfunction and airway or respiratory system compromise. Experimental studies have focused on stroke-induced immunosuppression and brain-lung crosstalk, leading to increased pulmonary damage and inflammation, as well as reduced alveolar macrophage phagocytic capability, which may increase the risk of infection. Pulmonary complications, such as respiratory failure, pneumonia, pleural effusions, acute respiratory distress syndrome, lung oedema, and pulmonary embolism from venous thromboembolism, are common and found to be among the major causes of death in this group of patients. Furthermore, over the past two decades, tracheostomy use has increased among stroke patients, who can have unique indications for this procedure-depending on the location and type of stroke-when compared to the general population. However, the optimal mechanical ventilator strategy remains unclear in this population. Although a high tidal volume (V
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.