ArticleVirology journal2019
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan's unique ecosystems against influenza viruses and paramyxoviruses.
Article in Virology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights.Molecules (Basel, Switzerland) · 2026Article
- Functional characteristics and distribution of microorganisms in saline and alkaline soils and their probiotic effects: a review.Microbial cell factories · 2026Review
- Beyond traditional screening: Unveiling antibiotic potentials of actinomycetes in extreme environments.Heliyon · 2024Article
- Alpha-sitosterol: a new antiviral agent produced by Streptomyces misakiensis and its potential activity against Newcastle disease virus.BMC veterinary research · 2024Article
- Antiviral activity of red algae phycocolloids against herpes simplex virus type 2Biotechnology reports (Amsterdam, Netherlands) · 2023Article
- Exploring the antimicrobial, antiviral, antioxidant, and antitumor potentials of marine Streptomyces tunisiensis W4MT573222 pigment isolated from Abu-Qir sediments, Egypt.Microbial cell factories · 2023Article
- Review
- Use of soil actinomycetes for pharmaceutical, food, agricultural, and environmental purposes.3 Biotech · 2022Review
- Streptomyces coeruleorubidus as a potential biocontrol agent for Newcastle disease virus.BMC veterinary research · 2022Article
- Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.Scientific reports · 2021Article
- Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.Research square · 2021Article
- Development and Effects of Influenza Antiviral Drugs.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to create new antiviral drugs from available compounds of natural products. It is known that the majority of drugs have been developed using compounds derived from actinomycetes, which are naturally occurring gram-positive bacteria. The purpose of this study was to investigate the antiviral properties of extremophilic actinomycetes extracts from strains that were isolated from extreme environments in Kazakhstan.
methodsFive strains of extremophilic actinomycetes isolated from the unique ecosystems of Kazakhstan were extracted and tested for antiviral activity against influenza viruses (strains H7N1, H5N3, H1N1 and H3N2) and paramyxoviruses (Sendai Virus and Newcastle Disease Virus). The antiviral activity of these selected extracts was tested by checking their effect on hemagglutination and neuraminidase activities of the studied viruses. Additionally, actinomycetes extracts were compared with commercially available antiviral drugs and some plant preparations that have been shown to exhibit antiviral properties.
resultsThe main findings show that extracts from strains K-192, K-340, K-362, K-522 and K525 showed antiviral activities when tested using influenza viruses, Sendai Virus, and Newcastle Disease Virus. These activities were comparable to those shown by Rimantadine and Tamiflu drugs, and "Virospan" and "Flavovir" plant preparations.
conclusionsWe identified several extracts with antiviral activities against several strains of influenza viruses and paramyxoviruses. Our research findings can be applied towards characterization and development of new antiviral drugs from the active actinomycetes extracts.
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