Evidence map›Paper›PMID 31791353›Full record

ArticleJournal of nanobiotechnology2019

Amplified intracellular Ca

Jian-Ping Dou, Qiong Wu, Chang-Hui Fu, Dong-Yun Zhang, Jie Yu, Xian-Wei Meng, Ping Liang

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  9. A Cecropin-4 Derived Peptide C18 InhibitsFrontiers in microbiology · 2022
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jian-Ping DouDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Qiong WuLaboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
Chang-Hui FuLaboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
Dong-Yun ZhangDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Jie YuDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. yu-jie301@hotmail.com.
Xian-Wei MengLaboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China. mengxw@mail.ipc.ac.cn.
Ping LiangDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. liangping301@126.com.
Chinese PLA General Hospital · CNTechnical Institute of Physics and Chemistry · CNChinese Academy of Sciences · CN

Funding

National Key R&D Program of China 2017YFC0112000National Natural Science Foundation 81622024National Natural Science Foundation 81627803National Natural Science Foundation 81801722
6 · The paper itself

Abstract

backgroundDeveloping new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of complications. We find that mild MW irradiation can significantly increase intracellular Ca

resultsThe as-made NaCl-DOX@PLGA nanoplatform selectively elevates the temperature of tumor tissue distributed with nanoparticles under low-output MW, which further prompts the release of DOX from the PLGA nanoparticles and tumor cellular uptake of DOX. More importantly, its synergistic effect not only combines thermal ablation and chemotherapy, but also obviously increases the intracellular Ca

conclusionsThis work provides a biocompatible and biodegradable nanoplatform with triple functions to realize the effective tumor killing in unlethal temperature. Those findings provide reliable solution to solve the bottleneck problem bothering clinics about the balance of thermal efficiency and normal tissue protection.

Indexed as

AnimalsAntibiotics, AntineoplasticCalciumDoxorubicinFemaleHep G2 CellsHumansHyperthermia, InducedMice, NudeMicrowavesNanoparticlesNeoplasmsPolylactic Acid-Polyglycolic Acid CopolymerAntibiotics, AntineoplasticCalciumDoxorubicinPolylactic Acid-Polyglycolic Acid CopolymerAblationChemotherapyIntracellular Ca2+Synergistic therapy

Identifiers

PMID31791353
PMCPMC6889637
OpenAlexW2994259151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.