ArticleRespiratory research2019
Relationship between diffusion capacity and small airway abnormality in COPDGene.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- The total-breath method yields higher values of DLCO and TLC than the conventional method.BMC pulmonary medicine · 2024Trial
- CT-based pulmonary vascular pruning and emphysema: clinical correlations and prognostic impacts in COPD.European radiology · 2026Article
- Clinical, Functional, and Comorbid Characteristics of COPD Patients with Impaired Diffusing Capacity: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Impulse oscillometry and traditional pulmonary function testing: correlation, advances and clinical implications.BMJ open respiratory research · 2026Review
- Article
- Association between impaired diffusion capacity and small airway dysfunction: a cross-sectional study.ERJ open research · 2025Article
- Comprehensive appraisal of lung function in young COPD patients: a single center observational study.BMC pulmonary medicine · 2024Observational
- Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Understanding Early COPD.Respiratory care · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.Respiratory research · 2023Article
- COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study.BMJ open respiratory research · 2023Article
- CT-Based Commercial Software Applications: Improving Patient Care Through Accurate COPD Subtyping.International journal of chronic obstructive pulmonary disease · 2022Review
- COPD - do the right thing.BMC family practice · 2021Review
- Evaluation of small airway function and its application in patients with chronic obstructive pulmonary disease (Review).Experimental and therapeutic medicine · 2021Review
- COPD Diagnosis: Time for Disruption.Journal of clinical medicine · 2021Review
- Pre-Chronic Obstructive Pulmonary Disease: Toward the Limits of the Spirometric Funnel.American journal of respiratory and critical care medicine · 2021Article
- Progression of Emphysema and Small Airways Disease in Cigarette Smokers.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- From GOLD 0 to Pre-COPD.American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease.
trial registrationNCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.