Evidence map›Paper›PMID 31791333›Full record

Trial reportNutrition journal2019

Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial.

Ida M Grønborg, Inge Tetens, Elisabeth Wreford Andersen, Michael Kristensen, Rikke E K Larsen, Thanh L L Tran, Rikke Andersen

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrition journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Vitamin DInternational journal of molecular sciences · 2023
    Review
  8. Review
  9. Effect of Vitamin D on Bone Regeneration: A Review.Medicina (Kaunas, Lithuania) · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ida M GrønborgNational Food Institute, Technical University of Denmark, Lyngby, Denmark. idamag@food.dtu.dk.ORCID 0000-0001-7316-1073
Inge TetensNational Food Institute, Technical University of Denmark, Lyngby, Denmark.
Elisabeth Wreford AndersenSection for Statistics and Pharmacoepidemiology, Danish Cancer Society, Copenhagen, Denmark.
Michael KristensenDepartment of Nursing and Nutrition, Faculty of Health, University College Copenhagen, Copenhagen, Denmark.
Rikke E K LarsenDepartment of Nursing and Nutrition, Faculty of Health, University College Copenhagen, Copenhagen, Denmark.
Thanh L L TranDepartment of Nursing and Nutrition, Faculty of Health, University College Copenhagen, Copenhagen, Denmark.
Rikke AndersenNational Food Institute, Technical University of Denmark, Lyngby, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeficient and insufficient vitamin D status (defined as serum 25(OH)D < 30 nmol/L and > 50 nmol/L) is prevalent worldwide and associated with decreased muscle strength and poor bone health. We aimed to investigate the effect of vitamin D fortification on bone markers and muscle strength among younger adult women at risk of vitamin D deficiency.

methodsA 12-week randomised double-blinded placebo-controlled winter intervention trial, providing 30 μg vitamin D

resultsSignificantly increased serum 25(OH)D concentration from 53.3 (17) to 77.8 (14) nmol/L and from 44.5 (21) to 54.7 (18) nmol/L among Danish and Pakistani women in the fortified groups, respectively (P <  0.05). The bone turnover markers OC, BALP, P1NP and CTX did not change significantly. Muscle strength by handgrip, knee extension and chair-standing test did not change significantly following the intervention.

conclusionsConsumption of vitamin D fortified foods for 12 weeks did not result in significant changes of the bone turnover markers OC, BALP, P1NP and CTX. Muscle strength measured as hand grip strength, knee extension strength and chair-standing did not change significantly following the intervention.

Indexed as

Food, FortifiedMuscle StrengthAdolescentAdultAlkaline PhosphataseBiomarkersBone RemodelingCollagen Type IDenmarkDouble-Blind MethodFemaleHumansMiddle AgedOsteocalcinPakistanPeptide FragmentsAlkaline PhosphataseBiomarkersCollagen Type IOsteocalcinPeptide FragmentsProcollagenprocollagen Type I N-terminal peptideVitamin DVitaminsBone regenerationBone resorptionFoodFortifiedImmigrantsMuscle strengthRanomised controlled trialVitamin D

Identifiers

PMID31791333
PMCPMC6889210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.