ArticleBMC oral health2019
Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults.
Article in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association between oral diseases and oral Helicobacter pylori infection: A systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Article
- Association ofMicroorganisms · 2025Review
- Does Helicobacter pylori have a role in the pathogenesis of otitis media with effusion, or is it a fallacy??European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Polymicrobial interactions ofJournal of oral microbiology · 2025Review
- Effect ofJournal of oral microbiology · 2025Article
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Selected Markers of Inflammation in the Saliva of Children Infected withInternational journal of molecular sciences · 2024Article
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- Review
- Analysis of Genetic Relatedness between Gastric and OralInternational journal of molecular sciences · 2023Article
- Detection ofMicroorganisms · 2022Article
- Review
- Association between dental caries and Helicobacter pylori infection in Japanese adults: A cross-sectional study.PloS one · 2022Article
- Review
- Nutrient Deficiency Promotes the Entry ofBiology · 2021Article
- The cross-kingdom interaction between Helicobacter pylori and Candida albicans.PLoS pathogens · 2021Article
- [Analysis of the association between helicobacter pylori infection and laryngeal lesions].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Distribution ofBiomedicines · 2020Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples.
methodsDental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry's outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection.
resultsTwenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries.
conclusionsH. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.