Observational studyBMC nephrology2019
Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.
Observational study in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Urinary Biomarkers for Diagnosis and Prediction of Acute Kidney Allograft Rejection: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Impact of Disease Recurrence and Outcomes following Kidney Transplantation for GN: A Prospective Nationwide Cohort Study.Kidney360 · 2026Article
- An exploratory comparison of the short-term effects of two different static cold storage techniques of the graft in kidney transplantation from living donors.Clinics (Sao Paulo, Brazil) · 2026Article
- Predictors of Long-Term Kidney Transplant Survival: A Scoping Review.Health science reports · 2026Review
- Ongoing and Novel Challenges in Kidney Transplantation: Therapeutic Approaches to Non-Immunological Risk Factors for Allograft Loss.Life (Basel, Switzerland) · 2026Review
- Kidney failure risk equation to predict kidney transplant failure in individuals with an eGFR<30 mL/min/1.73 mBMJ open · 2025Article
- The effects of intragraft CD38+ B cell on chronic active antibody mediated rejection in kidney transplantation.International urology and nephrology · 2025Article
- Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis.Kidney international reports · 2025Article
- Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting.Journal of nephrology · 2024Review
- Development of a checklist framework for kidney transplantation.Frontiers in transplantation · 2024Review
- Dialysis after kidney transplant failure: how to deal with this daunting task?Journal of nephrology · 2023Review
- Donor Proteinuria and Allograft Function in Kidney Transplantation: Short- and Long-Term Results From a Retrospective Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Clinical relevance of postoperative proteinuria for prediction of early renal outcomes after kidney transplantation.Kidney research and clinical practice · 2022Article
- Challenges in the Management of the Patient with a Failing Kidney Graft: A Narrative Review.Journal of clinical medicine · 2022Review
- Acute kidney injury secondary to urinary tract infection in kidney transplant recipients.Scientific reports · 2022Article
- Temporal changes of proteinuria after kidney transplantation: association with cardiovascular morbidity and mortality.Journal of nephrology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored.
methodsThis study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day.
resultsTransplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥ 44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (Hazard Ratio 2.77 vs Hazard Ratio 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥0.5 effect was more significant with donors > 50 years old (Odd Ratio 2.3).
conclusionsPost-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).
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