ArticleBMC geriatrics2019
Cardiovascular risk factors and memory decline in middle-aged and older adults: the English Longitudinal Study of Ageing.
Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular disease risk communication and prevention: a meta-analysis.European heart journal · 2024Pooled it
- Regional variability in the associations between social and health-related risk factors and memory across Europe.Scientific reports · 2026Article
- Demographic and biosocial determinants of beneficial trends in older adult cognition in the USA and England: the role of cohort succession.International journal of epidemiology · 2026Article
- Digital Twin Model of Treatment Outcomes in Post-Stroke Aphasia.medRxiv : the preprint server for health sciences · 2026Article
- Development and assessment of analytic methods to improve the measurement of cognition in longitudinal studies of aging through the use of substudies with comprehensive neuropsychological testing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The association of pre-cancer diagnosis cardiovascular risk factors with memory aging after a cancer diagnosis, overall and by race/ethnicity.Journal of cancer survivorship : research and practice · 2024Article
- Healthy lifestyle and cognitive decline in middle-aged and older adults residing in 14 European countries.Nature communications · 2024Article
- Effectiveness of tele-exercise training on physical fitness, functional capacity, and health-related quality of life in non-hospitalized individuals with COVID-19: The COFIT-HK study.Journal of exercise science and fitness · 2024Article
- Can Social Mobility Impact Frailty Trajectories of Chinese Adults in Later Life? A Nationwide Longitudinal Study.Innovation in aging · 2024Article
- Longitudinal Progression of White Matter Hyperintensity Severity in Chronic Stroke Aphasia.Archives of rehabilitation research and clinical translation · 2023Article
- Diabetes, brain health, and treatment gains in post-stroke aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Establishment of an Individual-Specific Nomogram for Predicting the Risk of Left Ventricular Hypertrophy in Chinese Postmenopausal Hypertensive Women.Medicina (Kaunas, Lithuania) · 2023Article
- Cardiovascular Risk Factors and Risk of Alzheimer Disease and Mortality: A Latent Class Approach.Journal of the American Heart Association · 2023Article
- Investigating longitudinal associations of hair cortisol and cortisone with cognitive functioning and dementia.Scientific reports · 2022Article
- Sex Differences in the Association Between Metabolic Dysregulation and Cognitive Aging: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Threshold effects of body mass index on cognitive function and heterogeneity by sex and cardiovascular risk factors.Frontiers in public health · 2022Article
- The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Sex differences and modifiable dementia risk factors synergistically influence memory over the adult lifespan.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- A Knowledge, Attitude, and Practice Survey on Medication Safety in Korean Older Adults: An Analysis of an Ageing Society.Healthcare (Basel, Switzerland) · 2021Article
- Multimorbidity Patterns and Memory Trajectories in Older Adults: Evidence From the English Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundWe investigated the association between trajectories of verbal episodic memory and burden of cardiovascular risk factors in middle-aged and older community-dwellers.
methodsWe analysed data from 4372 participants aged 50-64 and 3005 persons aged 65-79 years old from the English Longitudinal Study of Ageing who were repeatedly evaluated every 2 years and had six interviews of a 10-year follow-up. We measured the following baseline risk factors: diabetes, hypertension, smoking, physical inactivity and obesity to derive a cardiovascular risk factor score (CVRFs). Adjusted linear mixed effect regression models were estimated to determine the association between number of CVFRs and six repeated measurements of verbal memory scores, separately for middle-aged and older adults.
resultsCVRFs was not significantly associated with memory at baseline. CVFRs was significantly associated with memory decline in middle-aged (50-64y), but not in older (65-79y) participants. This association followed a dose-response pattern with increasing number of CVFRs being associated with greater cognitive decline. Comparisons between none versus some CVRFs yielded significant differences (p < 0.05).
conclusionsOur findings confirm that the effect of cumulative CVRFs on subsequent cognitive deterioration is age-dependent. CVRFs are associated with cognitive decline in people aged 50-64 years, but not in those aged ≥65 years. Although modest, the memory decline associated with accumulation of cardiovascular risk factors in midlife may increase the risk of late-life dementia.
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