Evidence map›Paper›PMID 31791173›Full record

ArticlemAbs

The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody.

Alessandro Masiero, Lechat Nelly, Gentric Marianne, Sourrouille Christophe, Laville Florian, Crépin Ronan, Borel Claire, Ziegler Cornelia, Bisch Grégoire, Leclerc Eric and 14 more

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An Unbound Proline-Rich Signaling Peptide Frequently SamplesFrontiers in molecular biosciences · 2021
    Article
  6. Article
  7. Polarity effects in 4-fluoro- and 4-(trifluoromethyl)prolines.Beilstein journal of organic chemistry · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Alessandro MasieroBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Lechat NellyBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Gentric MarianneBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Sourrouille ChristopheBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Laville FlorianBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Crépin RonanBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Borel ClaireBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Ziegler CorneliaBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Bisch GrégoireBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Leclerc EricBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Laurent LudovicBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Brault DominiqueBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Alexandre SylvieBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Gagnaire MarieBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Duffieux FrancisBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Soubrier FabienneBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Capdevila CécileBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Arnould IsabelleBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Dumas JacquesBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.
Dabin JérômeBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Genet BrunoBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Radošević KatarinaBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.ORCID 0000-0002-6769-8402
Menet Jean-MichelBiologics Development, SANOFI R&D, Vitry-sur-Seine, France.
Prades CatherineBiologics Research, SANOFI R&D, Vitry-sur-Seine, France.ORCID 0000-0002-7070-6602
Sanofi (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proline

Indexed as

Amino Acid MotifsChromatography, GelComplementarity Determining RegionsEpitopesHIV-1HIV AntibodiesHumansMolecular Dynamics SimulationProlineProtein BindingProtein ConformationStereoisomerismComplementarity Determining RegionsEpitopesHIV AntibodiesProlineantibody conformerschemical equilibriumdevelopabilityProline isomerization

Identifiers

PMID31791173
PMCPMC8675452
OpenAlexW2992632843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.