Evidence map›Paper›PMID 31791043›Full record

ArticlePediatric research2020

The effectiveness of urinary TIMP-2 and IGFBP-7 in predicting acute kidney injury in critically ill neonates.

Jiao Chen, Yunqing Sun, Sanfeng Wang, Xiaomei Dai, Hui Huang, Zhenjiang Bai, Xiaozhong Li, Jian Wang, Yanhong Li

Abstract read
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In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
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  7. Observational
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  9. Review
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  11. Article
  12. Early Diagnostic and Prognostic Value of the Urinary TIMP-2 and IGFBP-7 in Acute Kidney Injury in Critically Ill Children.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Gut microbiota and neonatal acute kidney injury biomarkers.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Neonatal acute kidney injury: a case-based approach.Pediatric nephrology (Berlin, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jiao Chen *Department of Pediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Yunqing Sun *Department of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Sanfeng WangDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Xiaomei DaiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Hui HuangDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Zhenjiang BaiDepartment of Pediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Xiaozhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Jian WangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, JiangSu province, China.
Yanhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, JiangSu province, China. lyh072006@hotmail.com.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroudUrinary tissue inhibitor of metalloproteinase-2 (TIMP-2), insulin-like growth factor binding protein-7 (IGFBP-7) and the combination of TIMP-2 and IGFBP-7 ([TIMP-2]•[IGFBP7]) are proposed to be predictive biomarkers for acute kidney injury (AKI). The intention of our study was to determine whether there is any significant predictive value of these biomarkers for the occurrence of AKI and severe AKI in critically ill neonates.

methodsUrinary samples were serially collected in 237 neonates during neonatal intensive care unit (NICU) stay for measurements of TIMP-2 and IGFBP-7 in this prospective study. AKI diagnosis was based on KDIGO classification without urine output or serum creatinine >1.2 mg/dL.

resultsTwenty neonates developed AKI, including 11 with KDIGO stage 1, defined as mild AKI, and 9 with stages 2 and 3, defined as severe AKI. Urinary IGFBP-7 and [TIMP-2]•[IGFBP7] remained associated with AKI after adjustment for gestational age, gender and illness severity. Urinary [TIMP-2]•[IGFBP7] achieved an AUC of 0.71 (P = 0.034) and displayed a sensitivity of 88.9% and a specificity of 50.9% for discriminating severe AKI at the optimal cut-off value of 0.045.

conclusionThe combination of TIMP-2 and IGFBP-7 had independent discriminative value for severe AKI in critically ill neonates.

Indexed as

Acute Kidney InjuryBiomarkersCritical IllnessFemaleHumansInfant, NewbornInsulin-Like Growth Factor Binding ProteinsIntensive Care Units, NeonatalMalePredictive Value of TestsProspective StudiesReproducibility of ResultsTissue Inhibitor of Metalloproteinase-2UrinalysisBiomarkersinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2

Identifiers

PMID31791043
OpenAlexW2990171875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.