Evidence map›Paper›PMID 31790954›Full record

ReviewAutonomic neuroscience : basic & clinical2020

Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides.

Georgios Theocharidis, Aristidis Veves

Open access · bronzeAbstract readReview
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 73 citations in OpenAlex.

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  20. Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Georgios TheocharidisJoslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Aristidis VevesJoslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: aveves@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · US

Funding

Skin Inflammatory Phenotypes as Biomarkers of Myocardial and Vascular RemodelingR01AG052282 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JEROSCH-HEROLD, MICHAEL, VEVES, ARISTIDIS · 2016 to 2020
$3.2M
Role of Macrophages in Impaired Wound Healing in Type 1 DiabetesDP3DK108224 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GARLICK, JONATHAN A, MOONEY, DAVID J · 2015 to 2015
$2.4M
Impaired Wound Healing in Diabetic Foot UlcerationR01DK076937 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VEVES, ARISTIDIS · 2007 to 2010
$1.4M
NIA NIH HHS R01 AG052282NIDDK NIH HHS DP3 DK108224NIDDK NIH HHS R01 DK076937
6 · The paper itself

Abstract

Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro- and anti- inflammatory cytokine response. Therefore to fully understand the contribution of autonomic nerve dysfunction in diabetic wound healing it is crucial to explore the implication of neuropeptides. Here, we will discuss recent studies elucidating the role of specific neuropeptides in wound healing.

Indexed as

Wound HealingAnimalsAutonomic PathwaysDiabetic NeuropathiesHumansNeuropeptidesSkin UlcerNeuropeptides

Identifiers

PMID31790954
PMCPMC6957730
OpenAlexW2989981476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.