Evidence map›Paper›PMID 31790847›Full record

ArticleBone2020

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children.

Ruixue Hou, Shelley A Cole, Mariaelisa Graff, Karin Haack, Sandra Laston, Anthony G Comuzzie, Nitesh R Mehta, Kathleen Ryan, Diana L Cousminer, Babette S Zemel and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ruixue HouDepartment of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Karin HaackPopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Sandra LastonSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas the Rio Grande Valley, Brownsville, TX, USA.
Anthony G ComuzzieThe Obesity Society, Silver Spring, MD, USA.
Nitesh R MehtaDepartment of Pediatrics and USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
Kathleen RyanDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Diana L CousminerDivision of Human Genetics, Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, USA; Department of Genetics, University of Pennsylvania, USA.
Babette S ZemelDivision of GI, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, USA.
Struan F A GrantDivision of Human Genetics, Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, USA; Department of Genetics, University of Pennsylvania, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Braxton D MitchellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Roman J ShypailoDepartment of Pediatrics and USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
Margaret L GourlayDepartment of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nancy F ButteDepartment of Pediatrics and USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
V Saroja VorugantiDepartment of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. Electronic address: saroja@unc.edu.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Quantitative Trait Locus Mapping in Human PedigreesR37MH059490 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2001 to 2010
$6.8M
Genome Wide Association Study of Bone Mineral Accretion During ChildhoodR01HD058886 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A, ZEMEL, BABETTE S · 2010 to 2013
$3.1M
Obesity and Diabetes Familial Risk in Hispanic ChildrenR01DK080457 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BUTTE, NANCY F. · 2009 to 2012
$2.5M
Comprehensive SNP Discovery in SLC2A9. A Candidate Gene for Uric Acid NephropathyR01DK092238 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VORUGANTI, VENKATA SAROJA · 2012 to 2015
$1.3M
QUANTITATIVE TRAIT LOCUS MAPPING IN HUMAN PEDIGREESR01MH059490 · NIMH · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI BLANGERO, JOHN · 1998 to 2000
$426k
Genetic determinants of puberty and later life health outcomesK99HD099330 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI COUSMINER, DIANA · 2019 to 2019
$132k
NICHD NIH HHS K99 HD099330NICHD NIH HHS R01 HD058886NIDDK NIH HHS R01 DK080457NIDDK NIH HHS R01 DK092238NIEHS NIH HHS P30 ES010126NIMH NIH HHS R01 MH059490NIMH NIH HHS R37 MH059490
6 · The paper itself

Abstract

contextOsteoporosis is a major public health burden with significant economic costs. However, the correlates of bone health in Hispanic children are understudied.

objectiveWe aimed to identify genetic variants associated with bone mineral density (BMD) and bone mineral content (BMC) at multiple skeletal sites in Hispanic children.

methodsWe conducted a cross-sectional genome-wide linkage analysis, genome-wide and exome-wide association analysis of BMD and BMC. The Viva La Familia Study is a family-based cohort with a total of 1030 Hispanic children (4-19 years old at baseline) conducted in Houston, TX. BMD and BMC were measured by Dual-energy X-ray absorptiometry.

resultsSignificant heritability were observed for BMC and BMD at multiple skeletal sites ranging between 44 and 68% (P < 2.8 × 10

conclusionsWe identified novel loci associated with BMC and BMD in Hispanic children, with strongest evidence for PTK2B. These findings provide better understanding of bone genetics and shed light on biological mechanisms underlying BMD and BMC variation.

Indexed as

Bone DensityOsteoporosisAbsorptiometry, PhotonAdolescentAdultChildChild, PreschoolCross-Sectional StudiesHispanic or LatinoHumansYoung AdultBoneChildrenGenetic variantsHispanicOsteoporosis

Identifiers

PMID31790847
PMCPMC7120871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.