Evidence map›Paper›PMID 31790809›Full record

Observational studyCellular and molecular gastroenterology and hepatology2020

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease.

Laura Cook, Daniel J Lisko, May Q Wong, Rosa V Garcia, Megan E Himmel, Ernest G Seidman, Brian Bressler, Megan K Levings, Theodore S Steiner

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cellular and molecular gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Flagellin in blood andiScience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Parallel analysis of multiple human memory CD4Immunology and cell biology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura CookDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Daniel J LiskoDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
May Q WongDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Rosa V GarciaBritish Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
Megan E HimmelBritish Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Ernest G SeidmanDivision of Gastroenterology, McGill University, Montréal, Quebec, Canada.
Brian BresslerDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Gastrointestinal Research Institute, Vancouver, British Columbia, Canada.
Megan K LevingsBritish Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
Theodore S SteinerDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: tsteiner@mail.ubc.ca.
University of British Columbia · CAMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

BACKGROUND &

aimsBacterial flagellin is an important antigen in inflammatory bowel disease, but the role of flagellin-specific CD4

methodsBlood was collected from 3 cohorts that included CD patients, UC patients, and healthy controls. Flow cytometry analyzed CD4

resultsCompared with healthy controls, CD and UC patients had lower frequencies of vaccine-antigen-specific CD4

conclusionsBoth CD and UC patients have relative increases in the proportion of circulating Fla2-specific CD4

Indexed as

Adaptive ImmunityAdolescentAdultAgedAntibodies, BacterialAntigens, BacterialCD4-Positive T-LymphocytesColitis, UlcerativeCrohn DiseaseCross-Sectional StudiesDNA, BacterialDysbiosisEnzyme-Linked Immunosorbent AssayEscherichia coli ProteinsEubacterialesFecesAntibodies, BacterialAntigens, BacterialDNA, BacterialEscherichia coli ProteinsFlagellinFliC protein, E coliRNA, Ribosomal, 16SCD4(+) T CellsCrohn’s DiseaseMicrobiomeUlcerative Colitis

Identifiers

PMID31790809
PMCPMC7036547
OpenAlexW2990370852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.