Evidence map›Paper›PMID 31790730›Full record

ReviewMethods (San Diego, Calif.)2020

Generation, purification and engineering of extracellular vesicles and their biomedical applications.

Jin Gao, Xinyue Dong, Zhenjia Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods (San Diego, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jin GaoDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Xinyue DongDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Zhenjia WangDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA. Electronic address: zhenjia.wang@wsu.edu.

Funding

Active Drug Loading to Nanovesicles for Targeted Drug DeliveryR01EB027078 · NIBIB · WASHINGTON STATE UNIVERSITY · PI WANG, ZHENJIA · 2019 to 2023
$1.4M
NIBIB NIH HHS R01 EB027078
6 · The paper itself

Abstract

Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be excellent therapeutics and drug carriers. Although EVs are promising, the process to develop high-quality and scalable EVs for their translation is demanding. Within this research, we analyzed the production of EVs, their purification and their post-bioengineering, and we also discussed the biomedical applications of EVs. We focus on the developments of methods in producing EVs including biological, physical, and chemical approaches. Furthermore, we discuss the challenges and the opportunities that arose when we translated EVs in clinic. With the advancements in nanotechnology and immunology, genetically engineering EVs is a new frontier in developing new therapeutics in order to tailor to individuals and different disease stages in treatments of cancer and inflammatory diseases.

Indexed as

BioengineeringBioreactorsCell Culture TechniquesCell MembraneCentrifugation, Density GradientDrug CompoundingDrug Delivery SystemsExtracellular VesiclesHelicobacter InfectionsHumansHydrogen-Ion ConcentrationInflammationNeoplasmsNeurodegenerative DiseasesPrecision MedicineSonicationBiomimetic vesiclesExosomesExtracellular vesiclesMicrovesiclesNitrogen cavitation

Identifiers

PMID31790730
PMCPMC7198327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.