Evidence map›Paper›PMID 31790581›Full record

ArticleJournal of medicinal chemistry2020

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA

Inés González-Gil, Debora Zian, Henar Vázquez-Villa, Gloria Hernández-Torres, R Fernando Martínez, Nora Khiar-Fernández, Richard Rivera, Yasuyuki Kihara, Isabel Devesa, Sakthikumar Mathivanan and 11 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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  7. Dual Role of Lysophosphatidic Acid Receptor 2 (LPAFrontiers in cellular neuroscience · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Inés González-GilDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Debora ZianDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Henar Vázquez-VillaDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0001-7911-3160
Gloria Hernández-TorresDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
R Fernando MartínezDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Nora Khiar-FernándezDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Richard RiveraSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
Yasuyuki KiharaSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
Isabel DevesaIDiBE, Universidad Miguel Hernández de Elche, E-03202 Alicante, Spain.
Sakthikumar MathivananIDiBE, Universidad Miguel Hernández de Elche, E-03202 Alicante, Spain.
Cristina Rosell Del ValleInstituto de Investigación Biomédica de Málaga, UGC Salud Mental, Universidad de Málaga, Hospital Universitario Regional de Málaga, E-29010 Málaga, Spain.
Emma Zambrana-InfantesInstituto de Investigación Biomédica de Málaga, UGC Salud Mental, Universidad de Málaga, Hospital Universitario Regional de Málaga, E-29010 Málaga, Spain.
María PuigdomenechDepartament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, E-08193 Barcelona, Spain.
Giovanni CincillaMolomics, Barcelona Science Park, Baldiri i Reixac 4-8, E-08028 Barcelona, Spain.
Melchor Sanchez-MartinezMolomics, Barcelona Science Park, Baldiri i Reixac 4-8, E-08028 Barcelona, Spain.
Fernando Rodríguez de FonsecaInstituto de Investigación Biomédica de Málaga, UGC Salud Mental, Universidad de Málaga, Hospital Universitario Regional de Málaga, E-29010 Málaga, Spain.
Antonio V Ferrer-MontielIDiBE, Universidad Miguel Hernández de Elche, E-03202 Alicante, Spain.
Jerold ChunSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
Rubén López-ValesDepartament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, E-08193 Barcelona, Spain.ORCID 0000-0001-7615-9550
María L López-RodríguezDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0001-8607-1085
Silvia Ortega-GutiérrezDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Universidad Complutense de Madrid · ESSanford Burnham Prebys Medical Discovery Institute · USUniversitat de Miguel Hernández d'Elx · ESInstituto de Investigación Biomédica de Málaga · ESUniversitat Autònoma de Barcelona · ES

Funding

Prenatal blood-borne lipids in post-hemorrhagic hydrocephalusR01NS084398 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI CHUN, JEROLD · 2014 to 2017
$2.6M
NINDS NIH HHS R01 NS084398
6 · The paper itself

Abstract

Neuropathic pain (NP) is a complex chronic pain state with a prevalence of almost 10% in the general population. Pharmacological options for NP are limited and weakly effective, so there is a need to develop more efficacious NP attenuating drugs. Activation of the type 1 lysophosphatidic acid (LPA

Indexed as

AnalgesicsAnimalsCell LineCell MovementCells, CulturedDrug DiscoveryFemaleHumansHydrocarbons, AromaticMice, Inbred C57BLModels, MolecularNeuralgiaPain PerceptionRats, WistarReceptors, Lysophosphatidic AcidSensory Receptor CellsAnalgesicsHydrocarbons, AromaticReceptors, Lysophosphatidic Acid

Identifiers

PMID31790581
PMCPMC7344333
OpenAlexW2994234749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.