ArticlePLoS pathogens2019
Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Tolerance to persistent cell-fusing agent virus infection in Aedes aegypti mosquitoes correlates with maintenance of lipid reserves.BMC biology · 2026Article
- Entomological Surveillance and Vector Competence: A Crucial Front in Dengue Prevention.Current topics in microbiology and immunology · 2026Review
- Heterogeneity in inhibition of genetically diverse dengue virus strains bybioRxiv : the preprint server for biology · 2025Article
- Dengue Virus Biosafety: An Analysis of Evidence, Global Inconsistencies, and Risk Gaps.Applied biosafety : journal of the American Biological Safety Association · 2025Review
- Comprehensive intra-host infection kinetics reveals high arbo-orthoflavivirus transmission potential by neglected vector species, Aedes scutellaris.PLoS neglected tropical diseases · 2025Article
- Exploring Mosquito Excreta as an Alternative Sample Type for Improving Arbovirus Surveillance in Australia.Pathogens (Basel, Switzerland) · 2025Article
- Larval crowding enhances dengue virus loads in Aedes aegypti, a relationship that might increase transmission in urban environments.PLoS neglected tropical diseases · 2024Article
- Bloodmeals fuel dengue virus replication in the female mosquitoJournal of virology · 2024Article
- Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics.PLoS pathogens · 2024Article
- No detectable fitness cost of infection by cell-fusing agent virus inRoyal Society open science · 2024Article
- Intra- and inter-host origin, evolution dynamics and spatial-temporal transmission characteristics of circoviruses.Frontiers in immunology · 2024Article
- Differential intra-host infection kinetics inmSphere · 2023Article
- Jamestown Canyon virus is transmissible by Aedes aegypti and is only moderately blocked by Wolbachia co-infection.PLoS neglected tropical diseases · 2023Article
- Engineered Human Tissue as A New Platform for Mosquito Bite-Site Biology Investigations.Insects · 2023Article
- Virulence decomposition for bifurcating infections.Proceedings. Biological sciences · 2023Article
- Dengue and chikungunya virus loads in the mosquito Aedes aegypti are determined by distinct genetic architectures.PLoS pathogens · 2023Article
- Dengue Virus-2 Infection Affects Fecundity and Elicits Specific Transcriptional Changes in the Ovaries ofFrontiers in microbiology · 2022Article
- Modeling cellular co-infection and reassortment of bluetongue virus inVirus evolution · 2022Article
- Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A.ACS pharmacology & translational science · 2021Article
- Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions.PLoS neglected tropical diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) transmission by mosquitoes is a time-dependent process that begins with the consumption of an infectious blood-meal. DENV infection then proceeds stepwise through the mosquito from the midgut to the carcass, and ultimately to the salivary glands, where it is secreted into saliva and then transmitted anew on a subsequent bite. We examined viral kinetics in tissues of the Aedes aegypti mosquito over a finely graded time course, and as per previous studies, found that initial viral dose and serotype strain diversity control infectivity. We also found that a threshold level of virus is required to establish body-wide infections and that replication kinetics in the early and intermediate tissues do not predict those of the salivary glands. Our findings have implications for mosquito GMO design, modeling the contribution of transmission to vector competence and the role of mosquito kinetics in the overall DENV epidemiological landscape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.