Evidence map›Paper›PMID 31790452›Full record

Trial reportPloS one2019

Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial.

Mariangela Ivette Guanipa Ortiz, Cristiane de Melo Alencar, Brennda Lucy Freitas De Paula, Eliane Bemerguy Alves, Jesuína Lamartine Nogueira Araújo, Cecy Martins Silva

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298059 (The Effect of Photobiomodulation Therapy Associated With Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride Paste on the Treatment of Post-home Whitening Tooth Sensitivity), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298059 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Photobiomodulation Therapy Associated With Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride Paste on the Treatment of Post-home Whitening Tooth Sensitivity: a Randomized Clinical Trial

TypeinterventionalSponsorUniversidade Federal do ParaRan2022 to 2023Enrolled50ConditionsSensitivity, ToothArmsLaser of low frequncy, CPP-ACPF
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Laser therapy for dentinal hypersensitivity.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mariangela Ivette Guanipa OrtizSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0003-1191-1339
Cristiane de Melo AlencarSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Brennda Lucy Freitas De PaulaSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Eliane Bemerguy AlvesSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Jesuína Lamartine Nogueira AraújoSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Cecy Martins SilvaSchool of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL).

methodsEighty teeth with DH were randomized into four groups and received three treatment sessions: PLACEBO = placebo + LASER application mimicking; CPP-ACPF = CPP-ACPF + LASER application mimicking; PBM = placebo + LASER active application; CPP-ACPF+PBM = CPP-ACPF + LASER active application. Tactile (exploratory probe) and evaporative (triple syringe) stimuli were used to measure DH and were recorded with the aid of a visual analogue scale (VAS) after the 1st, 2nd and 3rd treatment sessions and one-month follow-up. The HRQL was recorded in the DH experience questionnaire (DHEQ).

resultsThe intragroup comparison showed a significant reduction in DH (p < 0.05) with both stimuli after one-month follow-up. The intergroup comparison with the evaporative stimulus showed that CPP-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up. CPP-ACPF+PBM group statistically differed from the other treatment groups in the DHEQ evaluation after one-month follow-up.

conclusionAfter one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of this study.

Indexed as

AdolescentAdultCariostatic AgentsCaseinsCombined Modality TherapyDentin SensitivityDrug CombinationsFemaleFluorides, TopicalFollow-Up StudiesHumansLow-Level Light TherapyMaleMiddle AgedPain MeasurementPlacebosCariostatic Agentscasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsDrug CombinationsFluorides, TopicalPlacebos

Identifiers

PMID31790452
PMCPMC6886796
OpenAlexW2993749059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.