Evidence map›Paper›PMID 31790362›Full record

ArticleAging2019

Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017.

Hui Sun, Ting-Ting Gong, Yu-Ting Jiang, Shuang Zhang, Yu-Hong Zhao, Qi-Jun Wu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298657 (The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment), which is not on this map. Cited by 328 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
328citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298657 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment

Typeobservational_patient_registrySponsorFatima College of Health SciencesRan2022 to 2024Enrolled200ConditionsPoor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
3 · Its place in the literature

Who cites it

328 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  16. Molecular mechanisms of folliculogenesis and oogenesis.Systems biology in reproductive medicine · 2026
    Review
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268 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui SunDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Ting-Ting GongDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Yu-Ting JiangDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Shuang ZhangDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Yu-Hong ZhaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Qi-Jun WuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To provide comprehensive estimates of the global, regional, and national burden of infertility from 1990 to 2017, using findings from a 2017 study on the global burden of disease (GBD), we assessed the burden of infertility in 195 countries and territories from 1990 to 2017. DisMod-MR 2.1 is a Bayesian meta-regression method that estimates non-fatal outcomes using sparse and heterogeneous epidemiological data. Globally, the age-standardized prevalence rate of infertility increased by 0.370% per year for females and 0.291% per year for males from 1990 to 2017. Additionally, age-standardized disability-adjusted life-years (DALYs) of infertility increased by 0.396% per year for females and 0.293% per year for males during the observational period. An increasing trend to these burden estimates was observed throughout the all socio-demographic index (SDI) countries. Interestingly, we found that high SDI countries had the lowest level of prevalence and DALYs in both genders. However, the largest increasing trend was observed in high-SDI countries for females. By contrast, low-SDI countries had the largest increasing trend in males. Negative associations were observed between these burden estimates and the SDI level. The global disease burden of infertility has been increasing throughout the period from 1990 to 2017.

Indexed as

Global Burden of DiseaseBayes TheoremFemaleHumansInfertilityMalePrevalenceQuality-Adjusted Life Yearsdisability-adjusted life-yearsfemale infertilityglobal burden of disease studymale infertilityprevalence

Identifiers

PMID31790362
PMCPMC6932903

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.