ArticleJournal of studies on alcohol and drugs2019
Sex Differences in the Effect of Nucleus Accumbens Volume on Adolescent Drinking: The Mediating Role of Sensation Seeking in the NCANDA Sample.
Article in Journal of studies on alcohol and drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults.Alcohol, clinical & experimental research · 2023Trial
- Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking.Psychopharmacology · 2026Article
- Trends in Hospital Admissions for Psychoactive Substance Intoxication Among Children, Adolescents, and Young Adults in Slovenia, 2013-2023.Journal of clinical medicine · 2026Article
- Sex differences in reward network activation are linked to problematic substance use among high-risk adolescents.Advances in drug and alcohol research · 2025Article
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.Addiction biology · 2024Article
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.medRxiv : the preprint server for health sciences · 2023Article
- Alcohol and cannabis co-use and longitudinal gray matter volumetric changes in early and late adolescence.Addiction biology · 2022Article
- Parenting Styles as a Moderator of the Association between Pubertal Timing and Chinese Adolescents' Drinking Behavior.International journal of environmental research and public health · 2022Article
- Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward.Cognitive, affective & behavioral neuroscience · 2022Article
- Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review.Frontiers in neuroscience · 2022Review
- Ventral striatal resting-state functional connectivity in adolescents is associated with earlier onset of binge drinking.Drug and alcohol dependence · 2021Article
- Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.Neuropharmacology · 2021Review
- Trends of Hospitalization for Acute Alcohol Intoxication in Slovenian Children and Adolescents with and without Dual Disorder. Implications for a Correct Intervention.Journal of clinical medicine · 2020Article
- Increased Nucleus Accumbens Volume in College Binge Drinkers - Preliminary Evidence From Manually Segmented MRI Analysis.Frontiers in psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn adolescence, sensation seeking is associated with earlier onset of alcohol use, which is a risk factor for a variety of negative consequences later in life. Individual differences in sensation seeking are related to brain function in the nucleus accumbens (NAcc), a brain region that undergoes considerable structural development during adolescence. Therefore, the goal of this study was to determine whether NAcc volume in alcohol-naive adolescents was associated with future sensation seeking and alcohol use and whether these associations differed by sex.
methodHigh-resolution magnetic resonance imaging was used to measure NAcc volume at baseline in 514 alcohol-naive adolescents (50.2% female) from the National Consortium on Alcohol & Neurodevelopment in Adolescence study. Direct effects of NAcc volume on adolescent drinking 2 years after baseline, and indirect effects mediated through sensation seeking 1 year after baseline, were assessed.
resultsAn indirect effect of NAcc volume on subsequent drinking through sensation seeking was significant for males, but not females. This effect was driven by a positive association between NAcc volume and sensation seeking observed in male, but not female, participants. A direct effect of NAcc volume on subsequent alcohol use was detected in females, but not males. In females, no association between NAcc volume and sensation seeking was detected, but NAcc volume was positively associated with future alcohol use.
conclusionsThese findings suggest that delayed structural maturation of the NAcc may be a risk factor for alcohol use in adolescence; however, the mechanism by which the structure of the NAcc confers risk differs by sex.
Indexed as
Identifiers
31790349PMC6900990W2994400000What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.