ArticleAmerican journal of physiology. Renal physiology2020
Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Urologic Chronic Pelvic Pain Syndrome Flares: A Comprehensive, Systematic Review and Meta-Analysis of the Peer-Reviewed Flare Literature.The Journal of urology · 2024Pooled it
- Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025Review
- Acute urinary tract infection elicits bladder afferent hypersensitivity.Brain, behavior, & immunity - health · 2025Article
- Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.International journal of biological sciences · 2025Review
- Peripheral Mechanisms Underlying Bacillus Calmette-Guerin-Induced Lower Urinary Tract Symptoms (LUTS).Brain sciences · 2024Review
- TRPV1 and mast cell involvement in repeated variate stress-induced urinary bladder dysfunction in adult female mice.American journal of physiology. Renal physiology · 2024Article
- Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome.Nature reviews. Urology · 2024Review
- Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose.Scientific reports · 2024Article
- Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array.Scientific reports · 2024Article
- Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity.Science immunology · 2024Article
- Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives.International neurourology journal · 2024Article
- The role of nociceptive neurons in allergic rhinitis.Frontiers in immunology · 2024Review
- Prospective case-control study on pain intensity after the use of promethazine in patients undergoing videothoracoscopy.Frontiers in medicine · 2024Article
- Prevalence and allergy-related risk factors of overactive bladder in children in Northeast China.Frontiers in public health · 2024Article
- Lower Urinary Tract Symptoms (LUTS) as a New Clinical Presentation of Histamine Intolerance: A Prevalence Study of Genetic Diamine Oxidase Deficiency.Journal of clinical medicine · 2023Article
- Evaluation of the association between asthma and non-neurogenic urinary incontinence in children; a case-control study.BMC pediatrics · 2023Article
- Sensory Receptor, Inflammatory, and Apoptotic Protein Expression in the Bladder Urothelium of Patients with Different Subtypes of Interstitial Cystitis/Bladder Pain Syndrome.International journal of molecular sciences · 2023Article
- BCG induced lower urinary tract symptoms during treatment for NMIBC-Mechanisms and management strategies.Frontiers in neuroscience · 2023Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for hypersensitivity of bladder-innervating sensory neurons. The inflammatory mast cell mediator histamine has long been implicated in IC/BPS, yet the direct interactions between histamine and bladder afferents remain unclear. In the present study, we show, using a mouse ex vivo bladder afferent preparation, that intravesical histamine enhanced the mechanosensitivity of subpopulations of afferents to bladder distension. Histamine also recruited "silent afferents" that were previously unresponsive to bladder distension. Furthermore, in vivo intravesical histamine enhanced activation of dorsal horn neurons within the lumbosacral spinal cord, indicating increased afferent signaling in the central nervous system. Quantitative RT-PCR revealed significant expression of histamine receptor subtypes (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.