Evidence map›Paper›PMID 31790303›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Evidence for disordered acid-base handling in calcium stone-forming patients.

Elaine M Worcester, Kristin J Bergsland, Daniel L Gillen, Fredric L Coe

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Acid excretion is impaired in calcium oxalate stone formers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Elaine M WorcesterDepartment of Medicine, University of Chicago Medicine, Chicago, Illinois.ORCID 0000-0001-7989-2061
Kristin J BergslandDepartment of Medicine, University of Chicago Medicine, Chicago, Illinois.
Daniel L GillenDepartment of Statistics, University of California, Irvine, California.
Fredric L CoeDepartment of Medicine, University of Chicago Medicine, Chicago, Illinois.

Funding

STONE FORMATION IN GENETIC HYPERCALCIURIAP01DK056788 · NIDDK · UNIVERSITY OF CHICAGO · PI BERGSLAND, KRISTIN J · 2000 to 2021
$22.5M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430NIDDK NIH HHS P01 DK056788
6 · The paper itself

Abstract

In stone formers (SFs) with idiopathic hypercalciuria, urine pH governs the mineral phase of stones. Calcium phosphate (CaP) SFs have higher urine pH than calcium oxalate (CaOx) SFs. Normal women have higher urine pH than men on fixed diets, accompanied by greater absorption of food alkali. Female CaP and male CaOx SFs have similar urine pH as same sex normal individuals, but male CaP and female CaOx SFs may have abnormal acid-base handling. We studied 25 normal individuals (13 men and 12 women), 17 CaOx SFs (11 men and 6 women), and 15 CaP SFs (8 men and 7 women) on fixed diets. Urine and blood samples were collected under fasting and fed conditions. Female CaOx SFs had lower urine pH and lower alkali absorption, fed, compared with normal women; their urine NH

Indexed as

Acid-Base EquilibriumAcid-Base ImbalanceAdultAmmonium CompoundsBiomarkersCalcium OxalateCalcium PhosphatesCase-Control StudiesCitric AcidCrystallizationDietFemaleGastrointestinal AbsorptionHumansHydrogen-Ion ConcentrationHypercalciuriaAmmonium CompoundsBiomarkersCalcium Oxalatecalcium phosphateCalcium PhosphatesCitric Acidacid-basecalcium oxalatecalcium phosphatekidney stones

Identifiers

PMID31790303
PMCPMC7052659

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.