ArticleJournal of the American Chemical Society2019
Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Genomic and metabolomics analysis: unlocking the biocontrol mechanism of Trichoderma virilente Z53 against anthracnose in Pleione yunnanensis.BMC plant biology · 2026Article
- Epoxide Stereochemistry Controls Regioselective Ketoreduction in Epoxyquinoid Biosynthesis.Journal of the American Chemical Society · 2025Article
- Article
- A Toxin of Valsa mali Determines Virulence and Host Preference.Molecular plant pathology · 2025Article
- Formation ofOrganic letters · 2025Article
- Unveiling the Genomic Features and Biocontrol Potential ofJournal of fungi (Basel, Switzerland) · 2025Article
- Mapping epoxyquinoid biosynthesis: Enzyme functions across bacteria and fungi.Journal of industrial microbiology & biotechnology · 2024Review
- Biosynthetic Strategies of Berberine Bridge Enzyme-like Flavoprotein Oxidases toward Structural Diversification in Natural Product Biosynthesis.Biochemistry · 2024Review
- Genome Sequencing of Three Pathogenic Fungi Provides Insights into the Evolution and Pathogenic Mechanisms of the Cobweb Disease on Cultivated Mushrooms.Foods (Basel, Switzerland) · 2024Article
- Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates.Communications chemistry · 2024Article
- The histone deacetylase Hda1 affects oxidative and osmotic stress response as well as mycoparasitic activity and secondary metabolite biosynthesis inMicrobiology spectrum · 2024Article
- Penisimplicins A and B: Novel Polyketide-Peptide Hybrid Alkaloids from the FungusMolecules (Basel, Switzerland) · 2024Article
- Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining.Natural product reports · 2023Review
- Application of Gene Knockout and Heterologous Expression Strategy in Fungal Secondary Metabolites Biosynthesis.Marine drugs · 2022Review
- Total Heterologous Biosynthesis of Fungal Natural Products inJournal of natural products · 2022Review
- Genetic Evidence in Favor of a Polyketide Origin of Acremeremophilanes, the Fungal "Sesquiterpene" Metabolites.Microbiology spectrum · 2022Article
- Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk.Journal of fungi (Basel, Switzerland) · 2022Review
- Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories.Engineering microbiology · 2022Review
- Genome Sequencing and Analysis ofJournal of fungi (Basel, Switzerland) · 2022Article
- Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Fungal highly reducing polyketide synthases (HRPKSs) are highly programmed multidomain enzymes that synthesize reduced polyketide structures. Recent reports indicated salicylaldehydes are synthesized by HRPKS biosynthetic gene clusters, which are unexpected based on known enzymology of HRPKSs. Using genome mining of a
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.