ArticleAnatolian journal of cardiology2019
The prognostic value of altitude in patients with heart failure with reduced ejection fraction.
Article in Anatolian journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Myeloid Cell Expansion Propels Right Ventricular Dysfunction in HFpEF Through Sterile Inflammation.Circulation · 2026Article
- Association between baseline blood pressure variability and cardiac mechanics and electrophysiology after acute exposure to high altitude.BMC cardiovascular disorders · 2026Article
- Clinical and epidemiological characterization of heart failure patients in a high-altitude setting: a retrospective study at a tertiary hospital in Quito, Ecuador.Frontiers in cardiovascular medicine · 2026Article
- Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms.Current cardiology reviews · 2025Review
- Association of altitude with all-cause and cardiovascular mortality among patients with hypertension: a cohort study in Southwest China.BMC public health · 2024Article
- Work at high altitude and non-fatal cardiovascular disease associated with unfitness to work: Prospective cohort observation.PloS one · 2024Article
- Determinants of survival in patients with chronic heart failure: a population-based study in Reggio Emilia, Italy.ESC heart failure · 2023Article
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10 authors.
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Abstract
objectiveIt is well known that the altitude may affect the cardiovascular system. However, there were a few data related to the effect of altitude on the adverse outcome in patients with heart failure with reduced ejection fraction (HFREF). The aim of the present study was to investigate the role of intermediate high altitude on the major adverse cardiovascular outcome in patients with HFREF.
methodsPatients with HFREF admitted to the outpatient clinics at the first center at sea level and the second center at 1890 m were prospectively enrolled in the study. HFREF was defined as symptoms/signs of heart failure and left ventricular ejection fraction <40%. The major adverse cardiac outcome (MACE) was defined as all-cause death, stroke, and re-hospitalization due to heart failure. The median follow-up period of the study population was 27 months.
resultsThe study included 320 (58.55% male, mean age 65.7±11.2 years) patients. The incidence of all-cause death was 8.5%, stroke 6.1%, re-hospitalization due to decompensated heart failure 34.3%, and MACE 48.9%. In Kaplan-Meier analysis, patients with HFREF living at high altitude had more MACE (71.1% vs. 25.3%, log rank p=0.005) and presented with more stroke (11.3% vs. 2.1%, log rank p=0.001) and re-hospitalization due to heart failure (65.1% vs. 20.1%, log rank p<0.001) rates than those at low altitude in the follow-up; however, the rate of all-cause death was similar (9.4% vs. 8.1%, log rank p=0.245).
conclusionIn the present study, we demonstrated that the intermediate high altitude is the independent predictor of MACE in patients with HFREF. High altitude may be considered as a risk factor in decompensating heart failure.
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