ArticleAging2019
Metabolically healthy obesity reduces the risk of Alzheimer's disease in elders: a longitudinal study.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Dementia risk by metabolic health and obesity in two prospective cohorts.BMC medicine · 2026Article
- Metabolomic Pathways Distinguishing Metabolically Healthy and Unhealthy Obesity from Normal-Weight: A Cross-Sectional Study.International journal of molecular sciences · 2026Article
- Association of metabolic obesity phenotypes with cognitive decline in the ELSA-Brasil study.Diabetes, obesity & metabolism · 2026Article
- Association of mild cognitive impairment and obesity-metabolic status in middle-aged and elderly adults: a nationwide prospective cohort study.Journal of neurology · 2026Review
- A 6-year cohort study of the associations of body mass index, waist circumference, and waist-hip ratio with cognitive impairment in Chinese elderly.Frontiers in psychology · 2026Article
- Body mass index, metabolically abnormal status, and incident Parkinson's disease: Data from the UK Biobank.Journal of Parkinson's disease · 2025Article
- Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank.IBRO neuroscience reports · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies.Alzheimer's research & therapy · 2024Article
- Different associations between body mass index and Alzheimer's markers depending on metabolic health.Alzheimer's research & therapy · 2024Article
- Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity.Alzheimer's research & therapy · 2024Article
- Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study.BMC medicine · 2023Article
- Effects of Vascular Risk Factors on the Association of Blood-Based Biomarkers with Alzheimer's Disease.Medical research archives · 2023Article
- Comprehensive analysis of mRNAs in the cerebral cortex in APP/PS1 double-transgenic mice with Alzheimer's disease based on high-throughput sequencing of N4-acetylcytidine.Functional & integrative genomics · 2023Article
- Article
- Pathogenesis, Murine Models, and Clinical Implications of Metabolically Healthy Obesity.International journal of molecular sciences · 2022Review
- Body mass index related to executive function and hippocampal subregion volume in subjective cognitive decline.Frontiers in aging neuroscience · 2022Article
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
A subgroup of overweight/obese individuals, who had favorable metabolic profiles, was termed as metabolically healthy overweight/obese (MHO). Several studies suggested that MHO individuals were not at increased risk of cardiovascular disease and all-course mortality. However, whether MHO is associated with excess risk of Alzheimer's disease (AD) in elders remains unclear. To explore the risk of AD among MHO phenotype and investigate whether MHO associates with neurodegenerative biomarkers of AD, we assessed body mass index-metabolic status phenotypes of 1199 longitudinal elders from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Adult Treatment Panel-III (ATP- III) criteria. MHO subjects were at a significantly decreased risk for AD (adjusted HR=0.73, 95% CI: 0.54-0.97) compared with metabolically healthy normal weight (MHNW) subjects. In multivariable linear regression models, the cross-sectional associations of MHO with cerebrospinal fluid (CSF) biomarkers, brain Aβ load, and cortical structure were explored. MHO was positively correlated with CSF-Aβ (β=0.746, P=0.015), hippocampal volume (β=0.181, P=0.011), and whole brain volume (β=0.133, P=0.004). The MHO phenotype of the elder conferred a decreased risk of AD and its role may be driven by Aβ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.