ArticleHuman brain mapping2020
The right VLPFC and downregulation of social pain: A TMS study.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Effects of an open-label placebo intervention on reactions to social exclusion in healthy adults: a randomized controlled trial.Scientific reports · 2023Trial
- The role of ventrolateral prefrontal cortex on voluntary emotion regulation of social pain.Human brain mapping · 2023Trial
- The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback.Human brain mapping · 2022Trial
- Ventrolateral prefrontal-amygdala repetitive transcranial magnetic stimulation (rTMS) modulation of impulsivity in borderline personality disorder: a proof-of-concept study.Scientific reports · 2026Article
- Differential emotional responses and relief mechanisms across social exclusion roles.Cognitive, affective & behavioral neuroscience · 2026Article
- [Social pain: a clinically relevant literature review in primary care].Atencion primaria · 2026Article
- A causal and dissociable role for the right inferior frontal gyrus in empathy for physical and social pain.Cognitive, affective & behavioral neuroscience · 2026Article
- Resilience through regulation: Individual differences in inhibitory control shape neural and psychological responses to ostracism.Cognitive, affective & behavioral neuroscience · 2026Article
- Autonomic regulation during cognitive reappraisal in major depressive disorder: a study of fMRI correlates.BMC psychiatry · 2025Article
- Socially-Based Emotion Dysregulation Among Hearing-Impaired Adolescents: An Event-Related Potential Study.Brain and behavior · 2025Article
- Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination.Scientific reports · 2025Article
- Neural systems for processing social relationship information along two principal dimensions.Communications biology · 2025Article
- Modulatory role of the right ventrolateral prefrontal cortex in crowd emotional perception following social exclusion.Social cognitive and affective neuroscience · 2025Article
- Scarcity mindset facilitates empathy for social pain and prosocial intention: behavioral and neural evidences.Social cognitive and affective neuroscience · 2025Article
- Negative Emotion Differentiation Promotes Cognitive Reappraisal: Evidence From Electroencephalogram Oscillations and Phase-Amplitude Coupling.Human brain mapping · 2024Article
- Emotion regulation of social pain: double dissociation of lateral prefrontal cortices supporting reappraisal and distraction.Social cognitive and affective neuroscience · 2023Article
- The VLPFC-Engaged Voluntary Emotion Regulation: Combined TMS-fMRI Evidence for the Neural Circuit of Cognitive Reappraisal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Implicit, But Not Explicit, Emotion Regulation Relieves Unpleasant Neural Responses Evoked by High-Intensity Negative Images.Neuroscience bulletin · 2023Article
- Excitatory Dorsal Lateral Prefrontal Cortex Transcranial Magnetic Stimulation Increases Social Anxiety.Brain sciences · 2023Article
- You are fired! Exclusion words induce corticospinal modulations associated with vicarious pain.Social cognitive and affective neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regulation in physical- and social-pain conditions using repetitive transcranial magnetic stimulation (rTMS). A total of 60 healthy participants underwent active (n = 30) or sham (n = 30) rTMS over the RVLPFC. Following each TMS session, participants performed a non-reappraisal and then a reappraisal task to downregulate imagined physical or social pain evoked by pictures. Self-reported negative emotional ratings and electroencephalogram data were recorded during the emotion regulation task. Participants were then required to rate the valence and arousal of those pictures 30 min after the task. It is found that rTMS-activated RVLPFC led to reductions in subjective negative feelings and amplitudes of the late positive potential during reappraisal; however, these effects were found exclusively in the social-pain condition. Participants also reported higher positive valence for socially, compared to physically, painful pictures after 30 min of the task. Behavioral and electrophysiological evidence both supported the functional specificity of RVLPFC in regulation of social pain. The prominent delayed effect of rTMS makes it possible to consider the potential application of rTMS-VLPFC in clinical practice for social pain relief.
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