ReviewThe Journal of physiology2020
Mechano-electric and mechano-chemo-transduction in cardiomyocytes.
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Review in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Who cites it
25 citing papers in PubMed.
- A Model Framework for Ion Channels with Selectivity Filters Based on Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.International journal of molecular sciences · 2025Article
- Feature-Tracking Method Can Estimate Right Ventricular Contractile Properties in Rats With Pulmonary Hypertension.Circulation reports · 2025Article
- Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes.iScience · 2025Article
- The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect.Annual review of physiology · 2025Review
- Mechanisms of stretch-induced electro-anatomical remodeling and atrial arrhythmogenesis.Journal of molecular and cellular cardiology · 2024Review
- The heterocellular heart: identities, interactions, and implications for cardiology.Basic research in cardiology · 2023Review
- Article
- Low-intensity pulsed ultrasound of different intensities differently affects myocardial ischemia/reperfusion injury by modulating cardiac oxidative stress and inflammatory reaction.Frontiers in immunology · 2023Article
- Simultaneous assessment of radial and axial myocyte mechanics by combining atomic force microscopy and carbon fibre techniques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload-induced increases in CaThe Journal of physiology · 2022Article
- Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback.iScience · 2022Article
- The role of activation of two different sGC binding sites by NO-dependent and NO-independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes.Physiological reports · 2022Article
- Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies.Biomedicines · 2022Review
- Roles of stretch-activated channels and NADPH oxidase 2 in the induction of twitch contraction by muscle stretching in rat ventricular muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell-derived cardiomyocytes.The Journal of physiology · 2022Article
- Small conductance calcium activated KInternational journal of cardiology. Heart & vasculature · 2021Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A viscoelastic Eshelby inclusion model and analysis of the Cell-in-Gel system.International journal of engineering science · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Leighton T IzuDepartment of Pharmacology, University of California, Davis, CA, 95616, USA.ORCID 0000-0002-6552-9453
Peter KohlInstitute for Experimental Cardiovascular Medicine, University Heart Centre, and Faculty of Medicine, University of Freiburg, D-79110, Germany.
Penelope A BoydenDepartment of Pharmacology, Columbia University, NY, 10032, USA.
Masahito MiuraDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Tamas BanyaszDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Nipavan ChiamvimonvatDepartment of Internal Medicine, Cardiovascular Medicine, University of California, Davis, USA.ORCID 0000-0001-9499-8817
Natalia TrayanovaDepartment of Department of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, 95616, USA.ORCID 0000-0002-2237-9483
Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, CA, 95616, USA.ORCID 0000-0003-4818-9570
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MInfarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1MHigh-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure TherapyR01HL138539 · NHLBI · UNIVERSITY OF MINNESOTA · PI BERS, DONALD M, CORNEA, RAZVAN LIVIU · 2018 to 2021
$3.1MExploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8MThe Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7MMECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6MNovel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8MDecipher Mechano-Chemo-Transduction Pathway and Function in CardiomyocytesR01HL159993 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2021 to 2022
$1.5MSystems Approach to Understanding Cardiac Arrhythmias MechanismsR13HL147532 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, CHEN-IZU, YE · 2019 to 2019
$30kMechanics and Energetics in Cardiac Arrhythmias and Heart FailureR13HL139086 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, CHEN-IZU, YE · 2018 to 2018
$30kCSRD VA I01 CX001490NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL138539NHLBI NIH HHS R01 HL141460NHLBI NIH HHS R01 HL142496NHLBI NIH HHS R01 HL149431NHLBI NIH HHS R01 HL159993NHLBI NIH HHS R13 HL139086
Abstract
Cardiac excitation-contraction (E-C) coupling is influenced by (at least) three dynamic systems that couple and feedback to one another (see Abstract Figure). Here we review the mechanical effects on cardiomyocytes that include mechano-electro-transduction (commonly referred to as mechano-electric coupling, MEC) and mechano-chemo-transduction (MCT) mechanisms at cell and molecular levels which couple to Ca
Indexed as
Myocardial ContractionMyocytes, CardiacArrhythmias, CardiacExcitation Contraction CouplingHumansAnrep effectcardiac muscleexcitation-contraction couplingFrank-Starlingmechano-chemo-transductionmechano-electric couplingmyocardial contractility
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.