Evidence map›Paper›PMID 31788989›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2020

Biocorona-induced modifications in engineered nanomaterial-cellular interactions impacting biomedical applications.

Lisa Kobos, Jonathan Shannahan

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Interaction of TiOEnvironmental science. Nano · 2023
    Article
  9. Article
  10. Article
  11. Pulmonary iron oxide (FeHuman & experimental toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lisa KobosSchool of Health Sciences, College of Human and Health Sciences, Purdue University, West Lafayette, Indiana.
Jonathan ShannahanSchool of Health Sciences, College of Human and Health Sciences, Purdue University, West Lafayette, Indiana.ORCID 0000-0002-1065-7810

Funding

Disease-Induced Modification in Nanoparticle-Corona Identity and ToxicityR00ES024392 · NIEHS · PURDUE UNIVERSITY · PI SHANNAHAN, JONATHAN HENRY · 2017 to 2019
$747k
NIEHS NIH HHS R00 ES024392NIEHS NIH HHS R00/ES024392
6 · The paper itself

Abstract

When nanoparticles (NPs) enter a physiological environment, a complex coating of biomolecules is absorbed onto their surface, known as the biocorona (BC). This coating alters nanomaterial physical properties, modulating cellular viability, internalization, and immune responses. To safely utilize NPs within medical settings, it is necessary to understand the influence of the BC on cellular responses. Due to the variety of cell types, NPs, and physiological environments, responses are variable; though trends do exist. This review article critically evaluates the currently available literature regarding the influence of the BC on NP interactions with prominent cell types that they are likely to encounter during biomedical applications. Specifically, we will examine responses related to interactions with endothelial cells, macrophages, and epithelial cells of the digestive tract and lung. Further, we will evaluate how the BC may influence interactions with bacteria and fungi, as NPs have been proposed as antimicrobial agents in medical settings. The information reviewed and discussed here may enhance the development of effective of NP-based therapeutics and diagnostic tools. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Diagnostic Tools > Diagnostic Nanodevices.

Indexed as

Biomedical TechnologyCell CommunicationAnimalsCellsHumansNanostructuresProtein CoronaProtein Coronacell interactionscoronadisease environmentsnanomedicinetoxicology

Identifiers

PMID31788989
PMCPMC9567396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.