Evidence map›Paper›PMID 31788867›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.

Angelo Frei, Maite Amado, Matthew A Cooper, Mark A T Blaskovich

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Synthesis of aACS omega · 2025
    Article
  6. Article
  7. Review of Recent Medicinal Applications of Rhenium(I) Tricarbonyl Complexes.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy.Chembiochem : a European journal of chemical biology · 2023
    Review
  13. Article
  14. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angelo FreiInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0001-6169-2491
Maite AmadoInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072, Australia.
Matthew A CooperInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0003-3147-3460
Mark A T BlaskovichInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0001-9447-2292

Funding

Wellcome Trust WT1104797/Z/14/Z
6 · The paper itself

Abstract

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

Indexed as

Anti-Bacterial AgentsCoordination ComplexesEscherichia coliMethicillin-Resistant Staphylococcus aureusRheniumStaphylococcus aureusAnti-Bacterial AgentsCoordination ComplexesRheniumantibioticsdrug designmetal-based drugsrhenium

Identifiers

PMID31788867
PMCPMC7687258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.