Evidence map›Paper›PMID 31788858›Full record

ArticleMagnetic resonance in medicine2020

Improved pulmonary

Matthew M Willmering, Peter J Niedbalski, Hui Wang, Laura L Walkup, Ryan K Robison, James G Pipe, Zackary I Cleveland, Jason C Woods

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Magnetic resonance in medicine · 2025
    Article
  8. Article
  9. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. BMagnetic resonance in medicine · 2023
    Article
  16. Diffusion weighted hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  17. Review
  18. Review
  19. In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Matthew M WillmeringCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-4356-9622
Peter J NiedbalskiCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-0528-2508
Hui WangClinical Science, Philips, Cincinnati, Ohio.ORCID 0000-0002-0318-1316
Laura L WalkupCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ryan K RobisonDepartment of Radiology, Phoenix Children's Hospital, Phoenix, Arizona.ORCID 0000-0002-8244-0653
James G PipeDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jason C WoodsCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center · USMayo Clinic · USPhoenix Children's Hospital · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
Early detection of regional BOS in BMT patients using UTE and 129Xe MRIK99HL138255 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WALKUP, LAURA LEE · 2017 to 2018
$222k
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS K99 HL138255NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R44 HL123299NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

purposeHyperpolarized

methodsIn vivo human adult (N = 4; 2 healthy, 2 with cystic fibrosis)

resultsThe FLORET sequence obtained relative normalized SNR, 40% greater than 2D gradient-recalled echo (P = .012) and 26% greater than 3D radial (P = .067). Moreover, the FLORET images were acquired with 3-fold-higher nominal resolution in a 15% shorter breath-hold. Finally, vasculature was less prominent in FLORET, likely due to diminished susceptibility-induced dephasing at shorter TEs afforded by UTE sequences.

conclusionThe FLORET sequence yields higher SNR for a given resolution with a shorter breath-hold than traditional ventilation imaging techniques. This sequence more accurately measures ventilation abnormalities and enables reduced scan times in patients with poor compliance and severe lung disease.

Indexed as

Imaging, Three-DimensionalMagnetic Resonance ImagingAdultBreath HoldingHumansLungPulmonary VentilationRespiration129XeFLORETnon-CartesianspiralUTEventilation

Identifiers

PMID31788858
PMCPMC7083696
OpenAlexW2992795539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.